ArticleThe Annals of thoracic surgery2020
Renal Outcomes in Patients Bridged to Heart Transplant With a Left Ventricular Assist Device.
Article in The Annals of thoracic surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
- New kidney-after-heart allocation policy in the United States: Who would benefit from a rescue kidney?The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2025Article
- Induction Immunosuppression and Renal Outcomes in Adult Heart Transplantation.The Journal of surgical research · 2021Article
- Left Ventricular Assist Device under Chronic Kidney Disease: Cautious, But We Still Need More Details.International journal of heart failure · 2021Article
- Renal Function in Patients with or without a Left Ventricular Assist Device Implant During Listing for a Heart Transplant.Annals of transplantation · 2020Article
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundPatients with end-stage heart failure are increasingly being bridged to heart transplant (BTT) with mechanical circulatory support; however the association between a left ventricular assist device (LVAD) BTT strategy and posttransplant renal outcomes is unclear. The aim of this study was to analyze the association of LVAD BTT with the development of posttransplant renal failure using a large national registry.
methodsWe queried the 2009 to 2018 United Network for Organ Sharing registry for all adults undergoing first-time heart or heart-kidney transplantation and stratified patients by use of pretransplant durable LVAD. The primary outcome of interest was posttransplant renal failure, which was evaluated with multivariable logistic regression.
resultsOf 18,307 patients meeting inclusion criteria, 7887 were (43%) and 10,420 were not (57%) BTT with an LVAD. BTT patients had slightly better baseline renal function (estimated glomerular filtration rate, 68.7 vs 65.8 mL/min, P < .001) and were less likely to receive a heart-kidney transplant (2.7% vs 4.8%, P < .001). On multivariable logistic regression, LVAD BTT strategy was not independently associated with posttransplant renal failure (odds ratio, 1.13; 95% confidence interval, 0.86-1.49). Similarly LVAD BTT among patients with preoperative renal dysfunction was not associated with posttransplant renal failure (adjusted odds ratio, 1.40; 95% confidence interval, 0.91-2.18).
conclusionsBTT with an LVAD does not appear to be associated with worse renal outcomes regardless of baseline renal function. Furthermore, an LVAD BTT strategy in patients with chronic kidney disease may enable clinicians to identify candidates suitable for isolated heart transplantation without increasing their risk for posttransplant renal failure.
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