ArticleLife sciences2020
Sodium-hydrogen exchanger regulatory factor-1 (NHERF1) confers salt sensitivity in both male and female models of hypertension in aging.
Article in Life sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 7 citations in OpenAlex.
- Effect of High-Salt Diet on Memory and Behavior in Mice Expressing Human Apolipoprotein Epsilon-4 (APOE4) Allele.NeuroSci · 2026Article
- Associations Between Gut Microbiota, Short-Chain Fatty Acids, and High-Salt Diet-Induced Hypertension in Rats.Current medical science · 2025Article
- Mechanistic study of the effect of a high-salt diet on the intestinal barrier.Scientific reports · 2025Article
- Role of NHERF1 in MicroRNA Landscape Changes in Aging Mouse Kidneys.Biomolecules · 2024Article
- The Molecular Mechanisms Underlying the Systemic Effects Mediated by Parathormone in the Context of Chronic Kidney Disease.Current issues in molecular biology · 2024Review
- PPAR-α knockout leads to elevated blood pressure response to angiotensin II infusion associated with an increase in renal α-1 NaLife sciences · 2022Article
- Sex-specific adaptations to high-salt diet preserve electrolyte homeostasis with distinct sodium transporter profiles.American journal of physiology. Cell physiology · 2021Article
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
Hypertension is a risk factor for premature death and roughly 50% of hypertensive patients are salt-sensitive. The incidence of salt-sensitive hypertension increases with age. However, the mechanisms of salt-sensitive hypertension are not well understood. We had demonstrated decreased renal sodium‑hydrogen exchanger regulatory factor 1 (NHERF1) expression in old salt-resistant F344 rats. Based on those studies we hypothesized that NHERF1 expression is required for the development of some forms of salt-sensitive hypertension. To address this hypothesis, we measured blood pressure in NHERF1 expressing salt-sensitive 4-mo and 24-mo-old male and female Fischer Brown Norway (FBN) rats male and female 18-mo-old NHERF1 knock-out (NHERF1
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.