Evidence map›Paper›PMID 31904289›Full record

ArticleAmerican journal of physiology. Renal physiology2020

The expression level of class III phosphatidylinositol-3 kinase controls the degree of compensatory nephron hypertrophy.

Ting Liu, Caihong Dai, Jinxian Xu, Shude Li, Jian-Kang Chen

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Ting LiuDepartments of Cellular Biology and Anatomy and Medicine, Medical College of Georgia, Augusta University, Augusta, Gerogia.ORCID 0000-0002-8409-6227
Caihong DaiDepartments of Cellular Biology and Anatomy and Medicine, Medical College of Georgia, Augusta University, Augusta, Gerogia.
Jinxian XuDepartments of Cellular Biology and Anatomy and Medicine, Medical College of Georgia, Augusta University, Augusta, Gerogia.
Shude LiDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Kunming Medical University, Kunming, Yunnan, China.
Jian-Kang ChenDepartments of Cellular Biology and Anatomy and Medicine, Medical College of Georgia, Augusta University, Augusta, Gerogia.
Augusta University · USKunming Medical University · CN

Funding

Mechanisms Underlying the Susceptibility and Severity of Acute Kidney InjuryR01DK114328 · NIDDK · AUGUSTA UNIVERSITY · PI CHEN, JIAN-KANG · 2017 to 2021
$1.7M
Mechanism of Compensatory Renal HypertrophyR01DK083575 · NIDDK · VANDERBILT UNIVERSITY · PI CHEN, JIAN-KANG · 2011 to 2015
$1.7M
NIDDK NIH HHS R01 DK083575NIDDK NIH HHS R01 DK114328
6 · The paper itself

Abstract

Excessive compensatory nephron hypertrophy (CNH) has been implicated in setting the stage for progressive nephron damage. Lack of a class III phosphatidylinositol 3-kinase (Pik3c3) inhibitor suitable for using in animals and lack of a Pik3c3-deficient animal model preclude the possibility of conclusively defining a role for Pik3c3 in CNH in previous studies. Here, we report that insertion of an

Indexed as

AnimalsClass III Phosphatidylinositol 3-KinasesGene Expression Regulation, EnzymologicHypertrophyIntronsMechanistic Target of Rapamycin Complex 1MiceMutagenesis, InsertionalNephrectomyNephronsSignal TransductionClass III Phosphatidylinositol 3-KinasesMechanistic Target of Rapamycin Complex 1PIK3C3 protein, mouseclass III phosphatidylinositol-3 kinasecompensatory nephron hypertrophymammalian target of rapamycin complex 1ribosomal protein S6 phosphorylationunilateral nephrectomy

Identifiers

PMID31904289
PMCPMC7099500
OpenAlexW3000400246

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.