Evidence map›Paper›PMID 31904281›Full record

ArticleAmerican journal of physiology. Renal physiology2020

Loss of circadian gene

Dingguo Zhang, Chunhua Jin, Ijeoma E Obi, Megan K Rhoads, Reham H Soliman, Randee S Sedaka, J Miller Allan, Binli Tao, Joshua S Speed, Jennifer S Pollock and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
9.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 47 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Endothelin-1 signaling in the kidney: recent advances and remaining gaps.American journal of physiology. Renal physiology · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Hypertension disrupts the vascular clock in both sexes.American journal of physiology. Heart and circulatory physiology · 2024
    Article
  12. Review
  13. Recent advances in understanding the kidney circadian clock mechanism.American journal of physiology. Renal physiology · 2024
    Review
  14. Current perspective on circadian function of the kidney.American journal of physiology. Renal physiology · 2024
    Review
  15. Determination of the Relationship Between DNA Methylation Status ofBalkan journal of medical genetics : BJMG · 2023
    Article
  16. Review
  17. Article
  18. Male kidney-specific BMAL1 knockout mice are protected from KAmerican journal of physiology. Renal physiology · 2023
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Dingguo ZhangSection of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Chunhua JinSection of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Ijeoma E ObiSection of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Megan K RhoadsSection of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Reham H SolimanSection of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Randee S SedakaSection of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
J Miller AllanSection of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Binli TaoSection of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Joshua S SpeedDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi.
Jennifer S PollockSection of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
David M PollockSection of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.ORCID 0000-0002-0233-2362
University of Alabama at Birmingham · USJackson Memorial Hospital · US

Funding

Vascular and renal responses to stressP01HL069999 · NHLBI · MEDICAL COLLEGE OF GEORGIA (MCG) · PI GEORGE, VARGHESE · 2002 to 2018
$31.1M
Research Supplement to Promote DiversityP01HL136267 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI POLLOCK, DAVID M · 2017 to 2021
$11.9M
TRAINING IN CELLULAR PHYSIOLOGY MEMBRANE TRANSPORTT32DK007545 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GUTIERREZ, ORLANDO M · 1987 to 2023
$4.5M
Endothelin - Mechanisms in Hypertension and ObesityR00HL127178 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI SPEED, JOSHUA S · 2018 to 2020
$878k
Endothelin - Mechanisms in Hypertension and ObesityK99HL127178 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SPEED, JOSHUA S · 2016 to 2017
$308k
Novel Mechanisms of Nitric Oxide Activation in the KidneyF31DK111067 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SEDAKA, RANDEE · 2016 to 2018
$103k
NHLBI NIH HHS K99 HL127178NHLBI NIH HHS P01 HL069999NHLBI NIH HHS P01 HL136267NHLBI NIH HHS R00 HL127178NIDDK NIH HHS F31 DK111067NIDDK NIH HHS T32 DK007545
6 · The paper itself

Abstract

Kidney function follows a 24-h rhythm subject to regulation by circadian genes including the transcription factor

Indexed as

AldosteroneAnimalsARNTL Transcription FactorsBlood PressureFemaleGene Expression RegulationKidney Tubules, CollectingMaleMiceMice, KnockoutPotassiumReceptor, Endothelin BSex FactorsSodiumSodium Chloride, DietaryAldosteroneARNTL Transcription FactorsBmal1 protein, mousePotassiumReceptor, Endothelin BSodiumSodium Chloride, Dietarycircadian rhythmsclock genessex differences

Identifiers

PMID31904281
PMCPMC7099501
OpenAlexW2998979694

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.