Evidence map›Paper›PMID 31904133›Full record

ArticleProteins2020

V

Monica L Fernández-Quintero, Valentin J Hoerschinger, Leonida M Lamp, Alexander Bujotzek, Guy Georges, Klaus R Liedl

Abstract read
In one paragraph

Article in Proteins, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
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  7. Review
  8. Article
  9. Article
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  11. Article
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  15. Article
  16. VProteins · 2020
    Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Monica L Fernández-QuinteroInstitute of General, Inorganic and Theoretical Chemistry, and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain, Austria.
Valentin J HoerschingerInstitute of General, Inorganic and Theoretical Chemistry, and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain, Austria.
Leonida M LampInstitute of General, Inorganic and Theoretical Chemistry, and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain, Austria.
Alexander BujotzekRoche Pharma Research and Early Development, Large Molecule Research, Roche Innovation Center Munich, Penzberg, Germany.
Guy GeorgesRoche Pharma Research and Early Development, Large Molecule Research, Roche Innovation Center Munich, Penzberg, Germany.
Klaus R LiedlInstitute of General, Inorganic and Theoretical Chemistry, and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain, Austria.ORCID 0000-0002-0985-2299

Funding

Austrian Science Fund FWF P30565Austrian Science Fund FWF P30737
6 · The paper itself

Abstract

The relative orientation of the two variable domains, V

Indexed as

Binding SitesBinding Sites, AntibodyHumansImmunoglobulin Heavy ChainsImmunoglobulin Light ChainsInterleukin-1betaKineticsMolecular Dynamics SimulationNuclear Magnetic Resonance, BiomolecularProtein BindingProtein Conformation, alpha-HelicalProtein Conformation, beta-StrandProtein Interaction Domains and MotifsSingle-Chain AntibodiesThermodynamicsIL1B protein, humanImmunoglobulin Heavy ChainsImmunoglobulin Light ChainsInterleukin-1betaSingle-Chain Antibodiesantibodiesmolecular dynamics simulationsNMRVH and VL domain orientation

Identifiers

PMID31904133
PMCPMC7317758

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.