ArticleSleep2020
Sleep duration over 28 years, cognition, gray matter volume, and white matter microstructure: a prospective cohort study.
Article in Sleep, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Structural Brain Correlates of Insufficient Sleep in Adolescents: A Narrative Review of MRI Evidence.Children (Basel, Switzerland) · 2026Review
- Immune cell subsets linking insomnia trajectories and incident cognitive impairment: a prospective cohort study.BMC medicine · 2026Article
- Multi-organ imaging and genetics show the impact of sleep patterns on the human brain and body.Communications medicine · 2026Article
- Association of Sleep Duration With Intracranial Atherosclerosis and Cerebral Small Vessel Disease: A Mediation by Metabolic Factors.CNS neuroscience & therapeutics · 2026Observational
- Five-Year Changes in 24-Hour Sleep-Wake Activity and Dementia Risk in Oldest Old Women.Neurology · 2025Article
- Article
- Cross-sectional associations between 24-hour time-use composition, grey matter volume and cognitive function in healthy older adults.The international journal of behavioral nutrition and physical activity · 2024Article
- Trajectories of health conditions and their associations with the risk of cognitive impairment among older adults: insights from a national prospective cohort study.BMC medicine · 2024Article
- Association of Sleep Duration and Change Over Time With Imaging Biomarkers of Cerebrovascular, Amyloid, Tau, and Neurodegenerative Pathology.Neurology · 2024Article
- Causal associations between sleep traits and brain structure: a bidirectional Mendelian randomization study.Behavioral and brain functions : BBF · 2023Article
- The association of previous night's sleep duration with cognitive function among older adults: a pooled analysis of three Finnish cohorts.European journal of ageing · 2023Article
- Sleep function: an evolutionary perspective.The Lancet. Neurology · 2022Review
- Trajectories of Insomnia Symptoms Among Aging Employees and Their Associations With Memory, Learning Ability, and Concentration After Retirement - A Prospective Cohort Study (2000-2017).Journal of aging and health · 2022Article
- Cross-sectional and prospective associations between self-reported sleep characteristics and cognitive function in men and women: The Midlife in the United States study.Journal of sleep research · 2022Article
- The association between inadequate sleep and accelerated brain ageing.Neurobiology of aging · 2022Article
- Nighttime Sleep Characteristics and White Matter Integrity in Young Adults.Nature and science of sleep · 2022Article
- Short sleep duration and dementia: a narrative review.Proceedings (Baylor University. Medical Center) · 2022Review
- White matter microstructure and sleep-wake disturbances in individuals at ultra-high risk of psychosis.Frontiers in human neuroscience · 2022Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
12 authors.
Funding
Abstract
STUDY
objectivesTo examine the association between sleep duration trajectories over 28 years and measures of cognition, gray matter volume, and white matter microstructure. We hypothesize that consistently meeting sleep guidelines that recommend at least 7 hours of sleep per night will be associated with better cognition, greater gray matter volumes, higher fractional anisotropy, and lower radial diffusivity values.
methodsWe studied 613 participants (age 42.3 ± 5.03 years at baseline) who self-reported sleep duration at five time points between 1985 and 2013, and who had cognitive testing and magnetic resonance imaging administered at a single timepoint between 2012 and 2016. We applied latent class growth analysis to estimate membership into trajectory groups based on self-reported sleep duration over time. Analysis of gray matter volumes was carried out using FSL Voxel-Based-Morphometry and white matter microstructure using Tract Based Spatial Statistics. We assessed group differences in cognitive and MRI outcomes using nonparametric permutation testing.
resultsLatent class growth analysis identified four trajectory groups, with an average sleep duration of 5.4 ± 0.2 hours (5%, N = 29), 6.2 ± 0.3 hours (37%, N = 228), 7.0 ± 0.2 hours (45%, N = 278), and 7.9 ± 0.3 hours (13%, N = 78). No differences in cognition, gray matter, and white matter measures were detected between groups.
conclusionsOur null findings suggest that current sleep guidelines that recommend at least 7 hours of sleep per night may not be supported in relation to an association between sleep patterns and cognitive function or brain structure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.