Evidence map›Paper›PMID 31903849›Full record

ArticleXenobiotica; the fate of foreign compounds in biological systems2020

Risto O Juvonen, Olli Pentikäinen, Juhani Huuskonen, Juri Timonen, Olli Kärkkäinen, Aki Heikkinen, Muluneh Fashe, Hannu Raunio

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Xenobiotica; the fate of foreign compounds in biological systems, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Risto O JuvonenFaculty of Health Sciences, School of Pharmacy, University of Eastern Finland, Kuopio, Finland.
Olli PentikäinenFaculty of Medicine, Institute of Biomedicine, University of Turku, Turku, Finland.ORCID http://orcid.org/0000-0001-7188-4016
Juhani HuuskonenDepartment of Chemistry, University of Jyvaskyla, Jyvaskyla, Finland.
Juri TimonenFaculty of Health Sciences, School of Pharmacy, University of Eastern Finland, Kuopio, Finland.
Olli KärkkäinenFaculty of Health Sciences, School of Pharmacy, University of Eastern Finland, Kuopio, Finland.ORCID http://orcid.org/0000-0003-0825-4956
Aki HeikkinenAdmescope Ltd, Oulu, Finland.
Muluneh FasheReproductive & Developmental Biology Laboratory/Pharmacogenetics Group, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
Hannu RaunioFaculty of Health Sciences, School of Pharmacy, University of Eastern Finland, Kuopio, Finland.
University of Eastern Finland · FIMachida Endoscope (Japan) · JPNational Institute of Environmental Health Sciences · USUniversity of Jyväskylä · FIUniversity of Turku · FI

Funding

Structural Study Of SulfotransferasesZ01ES071005 · NIEHS · ENVIRONMENTAL HEALTH SCIENCES · PI NEGISHI, MASAHIKO · 1999 to 2007
$388k
Intramural NIH HHS Z01 ES071005
6 · The paper itself

Abstract

Sulfonation is an important high affinity elimination pathway for phenolic compounds.In this study sulfonation of 7-hydroxycoumarin and 13 its derivatives were evaluated in liver cytosols of human and six animal species. 7-hydroxycoumarin and its derivatives are strongly fluorescent, and their sulfate conjugates are nonfluorescent at excitation 405 nm and emission 460 nm. A convenient fluorescence based kinetic assay of sulfonation was established.The sulfonation rate of most of the 7-hydroxycoumarin derivatives was low in liver cytosol of human and pig, whereas it was high with most compounds in dog and intermediate in rat, mouse, rabbit, and sheep. Sulfonation of the 7-hydroxycoumarin derivatives followed Michaelis-Menten kinetics with

Indexed as

AnimalsCytosolDogsHumansMiceRabbitsRatsSheepSwineUmbelliferones7-hydroxycoumarinUmbelliferones7-hydroxycoumarinanimalhumanliverSulfonation

Identifiers

PMID31903849
PMCPMC7646200
OpenAlexW2997801628

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.