Evidence map›Paper›PMID 31903838›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2020

Persistent alterations in cerebrovascular reactivity in response to hypercapnia following pediatric mild traumatic brain injury.

Andrew B Dodd, Hanzhang Lu, Christopher J Wertz, Josef M Ling, Nicholas A Shaff, Benjamin C Wasserott, Timothy B Meier, Grace Park, Scott J Oglesbee, John P Phillips and 3 more

Abstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Cerebrovascular reactivity delay measured by blood oxygen level dependent magnetic resonance imaging and gas challenges: A systematic review.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Review
  3. Alterations of cerebrovascular reactivity following pediatric mild traumatic brain injury are independent of neurodevelopmental changes.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025
    Article
  4. Article
  5. Multifaceted neural and vascular pathologies after pediatric mild traumatic brain injury.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  6. Article
  7. Phosphodiesterase-5 (PDE-5) Inhibitors as Therapy for Cerebrovascular Dysfunction in Chronic Traumatic Brain Injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023
    Review
  8. Reduced and Delayed Cerebrovascular Reactivity in Patients with Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2023
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Persistent COJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
    Article
  14. Cerebrovascular Responses to OJournal of neurotrauma · 2021
    Article
  15. Brain BOLD MRI OCritical care (London, England) · 2020
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Andrew B DoddThe Mind Research Network/Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USA.
Hanzhang LuDepartment of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Christopher J WertzThe Mind Research Network/Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USA.
Josef M LingThe Mind Research Network/Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USA.
Nicholas A ShaffThe Mind Research Network/Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USA.
Benjamin C WasserottThe Mind Research Network/Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USA.
Timothy B MeierDepartment of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, USA.
Grace ParkDepartment of Pediatric Emergency Medicine, University of New Mexico, Albuquerque, NM, USA.
Scott J OglesbeeDepartment of Pediatric Emergency Medicine, University of New Mexico, Albuquerque, NM, USA.
John P PhillipsThe Mind Research Network/Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USA.
Richard A CampbellDepartment of Psychiatry, University of New Mexico, Albuquerque, NM, USA.
Peiying LiuDepartment of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Andrew R MayerThe Mind Research Network/Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USA.

Funding

University of New Mexico (UNM) Center for Brain Recovery and RepairP20GM109089 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI SHUTTLEWORTH, CLAUDE W · 2015 to 2024
$22.7M
The Impact of Diffuse Mild Brain Injury on Clinical Outcomes in ChildrenR01NS098494 · NINDS · THE MIND RESEARCH NETWORK · PI Andrew Robert Mayer · 2016 to 2026
$7.6M
NIGMS NIH HHS P20 GM109089NINDS NIH HHS R01 NS098494
6 · The paper itself

Abstract

Much attention has been paid to the effects of mild traumatic brain injury (mTBI) on cerebrovascular reactivity in adult populations, yet it remains understudied in pediatric injury. In this study, 30 adolescents (12-18 years old) with pediatric mTBI (pmTBI) and 35 age- and sex-matched healthy controls (HC) underwent clinical and neuroimaging assessments during sub-acute (6.9 ± 2.2 days) and early chronic (120.4 ± 11.7 days) phases of injury. Relative to controls, pmTBI reported greater initial post-concussion symptoms, headache, pain, and anxiety, resolving by four months post-injury. Patients reported increased sleep issues and exhibited deficits in processing speed and attention across both visits. In grey-white matter interface areas throughout the brain, pmTBI displayed increased maximal fit/amplitude of a time-shifted end-tidal CO

Indexed as

AdolescentAnxietyBrain ConcussionCarbon DioxideCase-Control StudiesCerebrovascular CirculationChildFemaleGray MatterHeadacheHumansHypercapniaMaleNeuroimagingPainPost-Concussion SyndromeCarbon DioxideCerebral blood flowcerebrovascular reactivityconcussionfunctional magnetic resonance imagingpediatric mild traumatic brain injury

Identifiers

PMID31903838
PMCPMC7820694

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.