Evidence map›Paper›PMID 31903789›Full record

ArticleJournal of drug targeting2020

Liposomal delivery of hydrophobic RAMBAs provides good bioavailability and significant enhancement of retinoic acid signalling in neuroblastoma tumour cells.

Maja Bilip, Shreya Shah, Mayuran Mathiyalakan, Aristides D Tagalakis, Stephen L Hart, Ruhina Maeshima, Simon Eaton, Michael Orford, Elsa Irving, Alessia Di Florio and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of drug targeting, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. New luciferin-based probe substrates for human CYP26A1.Biochemistry and biophysics reports · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Maja BilipGreat Ormond Street Institute of Child Health, UCL, London, UK.
Shreya ShahGreat Ormond Street Institute of Child Health, UCL, London, UK.
Mayuran MathiyalakanGreat Ormond Street Institute of Child Health, UCL, London, UK.
Aristides D TagalakisGreat Ormond Street Institute of Child Health, UCL, London, UK.
Stephen L HartGreat Ormond Street Institute of Child Health, UCL, London, UK.
Ruhina MaeshimaGreat Ormond Street Institute of Child Health, UCL, London, UK.
Simon EatonGreat Ormond Street Institute of Child Health, UCL, London, UK.
Michael OrfordGreat Ormond Street Institute of Child Health, UCL, London, UK.
Elsa IrvingGreat Ormond Street Institute of Child Health, UCL, London, UK.
Alessia Di FlorioGreat Ormond Street Institute of Child Health, UCL, London, UK.
Claire SimonsGreat Ormond Street Institute of Child Health, UCL, London, UK.
Andrew W StokerGreat Ormond Street Institute of Child Health, UCL, London, UK.ORCID 0000-0001-8902-5682
Great Ormond Street Hospital · GB

Funding

Department of HealthMedical Research Council
6 · The paper itself

Abstract

Retinoid treatment is employed during residual disease treatment in neuroblastoma, where the aim is to induce neural differentiation or death in tumour cells. However, although therapeutically effective, retinoids have only modest benefits and suffer from poor pharmacokinetic properties.

Indexed as

AzolesCell Line, TumorCell SurvivalGene Expression Regulation, EnzymologicGene Expression Regulation, NeoplasticHumansLiposomesNeuroblastomaProto-Oncogene Proteins c-aktRetinoic Acid 4-HydroxylaseSignal TransductionTretinoinAzolesCYP26A1 protein, humanCYP26B1 protein, humanLiposomesProto-Oncogene Proteins c-aktRetinoic Acid 4-HydroxylaseTretinoinCYP26liposomeneural differentiationNeuroblastomaRAMBAretinoic acid

Identifiers

PMID31903789
PMCPMC7609071
OpenAlexW2998208580

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.