Evidence map›Paper›PMID 31903715›Full record

ArticleAging cell2020

Intrinsically altered lung-resident γδT cells control lung melanoma by producing interleukin-17A in the elderly.

Min Cheng, Yongyan Chen, Dake Huang, Wen Chen, Weiping Xu, Yin Chen, Guodong Shen, Tingjuan Xu, Gan Shen, Zhigang Tian and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Min ChengGerontology Institute of Anhui Province, The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital), Hefei, China.ORCID 0000-0003-2448-8365
Yongyan ChenInstitute of Immunology and The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Science and Medical Center, University of Science and Technology of China, Hefei, China.
Dake HuangComprehensive Laboratory, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.
Wen ChenGerontology Institute of Anhui Province, The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital), Hefei, China.
Weiping XuGerontology Institute of Anhui Province, The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital), Hefei, China.
Yin ChenGerontology Institute of Anhui Province, The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital), Hefei, China.
Guodong ShenGerontology Institute of Anhui Province, The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital), Hefei, China.
Tingjuan XuGerontology Institute of Anhui Province, The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital), Hefei, China.
Gan ShenGerontology Institute of Anhui Province, The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital), Hefei, China.
Zhigang TianCancer Immunotherapy Center, The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital), Hefei, China.
Shilian HuGerontology Institute of Anhui Province, The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital), Hefei, China.
University of Science and Technology of China · CNAnhui Medical University · CN

Funding

Anhui Provincial Project of the Key Laboratory of Tumor Immunotherapy and Nutrition Therapy 2018080503B0031National Natural Science Foundation of China 81471552
6 · The paper itself

Abstract

Cancer is an age-associated disease, potentially related to the altered immune system of elderly individuals. However, cancer has gradually decreased incidence in the eldest globally such as the most common lung cancer, the mechanisms of which remain to be elucidated. In this study, it was found that the number of lung-resident γδT cells was significantly increased with altered gene expression in aged mice (20-24 months) versus young mice (10-16 weeks). Aged lung Vγ4

Indexed as

AgedAgingAnimalsAntigens, CDFemaleGene Expression Regulation, NeoplasticGene OntologyHumansImmunotherapyIntegrin alpha ChainsInterleukin-17Intraepithelial LymphocytesLungLung NeoplasmsMelanoma, ExperimentalMicealpha E integrinsAntigens, CDIl17a protein, mouseIntegrin alpha ChainsInterleukin-17agingcommensal microbiotainterleukin-17Alung cancerlung-resident γδT cell

Identifiers

PMID31903715
PMCPMC6996947
OpenAlexW2997248883

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.