ArticleClinical transplantation2020
Discontinuing amiodarone treatment prior to heart transplantation lowers incidence of severe primary graft dysfunction.
Article in Clinical transplantation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 18 citations in OpenAlex.
- Amiodarone use prior to cardiac transplant in children is associated with increased need for post-transplant chronotropic support.JHLT open · 2026Article
- Risk factors for primary graft dysfunction after heart transplantation-a systematic review and meta-analysis.JHLT open · 2026Review
- Article
- Optimization of pretransplant amiodarone therapy to prevent primary graft dysfunction following heart transplantation.JHLT open · 2025Article
- The Interaction of Amiodarone and Continuous-flow Left Ventricular Assist Device Use in Risk of Severe Primary Graft Dysfunction Following Heart Transplantation.Transplantation direct · 2022Article
- Vasoplegia from Continuous Flow Left Ventricular Assist Devices.Current cardiology reports · 2021Review
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
backgroundRecent studies have shown an increased incidence of primary graft dysfunction (PGD) in patients treated with amiodarone prior to orthotopic heart transplant (OHT). We hypothesized that discontinuation of amiodarone before OHT may lower the incidence of severe PGD.
methodsThis was a single-center retrospective study of 381 adult OHT recipients between January 2010 and June 2017. Within 6 months prior to OHT, 197 did not receive amiodarone (Group 1), 142 continued amiodarone to OHT (Group 2), and 42 had amiodarone treatment discontinued before OHT (Group 3).
results53 (13.9%) participants developed severe PGD, 13 (6.6%) of which were in Group 1, 36 (25.4%) were in Group 2, and 4 (9.5%) were in Group 3 (P < .001). Multivariable analysis revealed continued amiodarone treatment to OHT (Group 2; OR, 3.70; 95% CI, 1.26-10.88; P = .018) to be an independent risk factor for the development of severe PGD when Group 1 served as the reference group. Moreover, patients in Group 3 had no difference in the risk of severe PGD (OR = 0.416, 95% CI = 0.08-2.15; P = .296).
conclusionWe found that discontinuing amiodarone treatment prior to OHT resulted a lower incidence of severe PGD.
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