Evidence map›Paper›PMID 31903573›Full record

Observational studyAnaesthesia2020

The association between genome-wide polymorphisms and chronic postoperative pain: a prospective observational study.

R R I van Reij, D M N Hoofwijk, B P F Rutten, L Weinhold, M Leber, E A J Joosten, A Ramirez, N J van den Hoogen, Italian Pain Group

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Anaesthesia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 3 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. A Reference Atlas of the Human Dorsal Root Ganglion.bioRxiv : the preprint server for biology · 2025
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  15. The mechanisms and management of persistent postsurgical pain.Frontiers in pain research (Lausanne, Switzerland) · 2023
    Review
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

R R I van ReijDepartment of Anaesthesiology and Pain Management, Maastricht University Medical Center, Maastricht, the Netherlands.
D M N HoofwijkSchool for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, University of Maastricht, the Netherlands.
B P F RuttenDepartment of Psychiatry and Neuropsychology, Faculty of Health, Medicine and Life Sciences, University of Maastricht, the Netherlands.
L WeinholdDepartment of Medical Biometry, Informatics and Epidemiology, University Hospital Bonn, Germany.
M LeberDepartment of Psychiatry and Psychotherapy, University of Cologne, Germany.
E A J JoostenDepartment of Anaesthesiology and Pain Management, Maastricht University Medical Center, Maastricht, the Netherlands.
A RamirezDepartment of Psychiatry and Psychotherapy, University of Bonn, Germany.
N J van den HoogenDepartment of Anaesthesiology and Pain Management, Maastricht University Medical Center, Maastricht, the Netherlands.
Italian Pain Group
Maastricht University · NLUniversity of Bonn · DEUniversity of Cologne · DEZimmer Biomet (Germany) · DE

Funding

Development of Conjugated Oligonucleotide Therapeutics for Neuronal DiseaseR43TR002702 · NCATS · DTX PHARMA, LLC · PI SUCKOW, ARTHUR THOMAS · 2019 to 2019
$301k
NCATS NIH HHS R43 TR002702
6 · The paper itself

Abstract

Chronic postoperative pain is common and can have a negative impact on quality of life. Recent studies show that genetic risk factors are likely to play a role, although only gene-targeted analysis has been used to date. This is the first genome-wide association study to identify single-nucleotide polymorphisms associated with the development of chronic postoperative pain based on two independent cohorts. In a discovery cohort, 330 women scheduled for hysterectomy were genotyped. A case-control association analysis compared patients without chronic postoperative pain and the 34 who had severe chronic postoperative pain 3 months after surgery. No single-nucleotide polymorphisms reached genome-wide significance, but several showed suggestive associations with chronic postoperative pain (p < 1 × 10

Indexed as

AgedChronic PainFemaleFollow-Up StudiesGenome-Wide Association StudyHumansMiddle AgedPolymorphism, Single NucleotidePostoperative PainProspective Studieschronic paingenome-wide association studyrisk factors

Identifiers

PMID31903573
PMCPMC6973279
OpenAlexW2999545556

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.