Evidence map›Paper›PMID 31903501›Full record

ArticleClinical oral investigations2020

Analysis of risk factors for multiple primary oral squamous cell carcinoma: a cohort study.

Xiaoyu Lin, Xiaoshan Wu, Aly Gomaa, Jie Chen, Limeng Wu, Xiaoyue Xie, Yaqin Hu, Canhua Jiang

Abstract read
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In one paragraph

Article in Clinical oral investigations, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
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  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
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  11. Article
  12. Chemical Composition, Pharmacological, and Toxicological Effects of Betel Nut.Evidence-based complementary and alternative medicine : eCAM · 2021
    Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Xiaoyu LinDepartment of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Xiaoshan WuDepartment of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Aly GomaaDepartment of Oral and Maxillofacial Surgery, Faculty of Dentistry, Minia University, Minya, 11435, Egypt.
Jie ChenDepartment of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Limeng WuDepartment of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Xiaoyue XieAcademy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing, 100190, China.
Yaqin HuDepartment of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Canhua JiangDepartment of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China. canhuaj@csu.edu.cn.
Central South University · CNXiangya Hospital Central South University · CNAcademy of Mathematics and Systems Science · CNMinia University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveChewing betel quid (CBQ) is popular in Southeast Asia, resulting in a high incidence of oral squamous cell carcinoma (OSCC). The incidence of multiple primary oral cancer (MPOC) has gradually increased and has become one of the main causes of OSCC treatment failure. However, it is unclear whether the high incidence of MPOC is also correlated with the habit of CBQ. MATERIALS AND

methodsIn this retrospective study, 915 OSCC patients were enrolled. MPOC incidence and characteristics were analyzed. CBQ and other risk factors for MPOC were investigated by chi-squared test and logistic stepwise regression analysis.

resultsAmong 915 patients, 15 were diagnosed with synchronous MPOC. After follow-up, 60 of 915 patients developed a second or third primary lesion site and were diagnosed with metachronous MPOC. The remaining 840 patients were then diagnosed with single primary oral cancer (SPOC). The cumulative incidence of MPOC in all OSCC patients was 8.2%. CBQ and the related oral submucous fibrosis (OSF) were found to be independent risk factors of MPOC (P < 0.001). Both MPOC and SPOC patients with a CBQ habit were much younger than those who did not have a CBQ habit (P < 0.001). The buccal mucosa was the most common primary occurrence site (35.9%) in MPOC cases, and almost all MPOC patients with buccal cancer had previously suffered from OSF (88.9%).

conclusionCBQ and CBQ-related OSF, for the first time, are identified as the independent risk factors of MPOC. Prevention and treatment of OSF as well as cessation of CBQ are expected to become new approaches to reduce the incidence of MPOC. CLINICAL RELEVANCE: More frequent physical examinations should be undertaken in OSCC patients with CBQ or CBQ-related OSF.

Indexed as

Carcinoma, Squamous CellMouth NeoplasmsNeoplasms, Multiple PrimaryOral Submucous FibrosisCohort StudiesHumansRetrospective StudiesRisk FactorsChewing betel quidMultiple primary oral cancerOral squamous cell carcinomaRisk factor

Identifiers

PMID31903501
OpenAlexW2998402621

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.