ArticleChem2019
Expanding the materials space of DNA via organic-phase ring-opening metathesis polymerization.
Article in Chem, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Epidemiology and genetic analysis ofJournal of veterinary research · 2025Article
- Beyond Lipids: Exploring Advances in Polymeric Gene Delivery in the Lipid Nanoparticles Era.Advanced materials (Deerfield Beach, Fla.) · 2024Review
- Supramolecular DNA-based catalysis in organic solvents.iScience · 2024Article
- Nucleic Acid-Binding Dyes as Versatile Photocatalysts for Atom-Transfer Radical Polymerization.Journal of the American Chemical Society · 2024Article
- Biomass RNA for the Controlled Synthesis of Degradable Networks by Radical Polymerization.ACS nano · 2023Article
- Synthesis of RNA-Amphiphiles via Atom Transfer Radical Polymerization in the Organic Phase.Precision chemistry · 2023Article
- Exploring the Structural Diversity of DNA Bottlebrush Polymers Using an Oligonucleotide Macromonomer Approach.Macromolecules · 2022Article
- Origin of Proteolytic Stability of Peptide-Brush Polymers as Globular Proteomimetics.ACS central science · 2021Article
- Degradable polymers via olefin metathesis polymerization.Progress in polymer science · 2021Article
- DNA-polymer conjugatesChemical communications (Cambridge, England) · 2021Article
- Synthetic Approaches for Copolymers Containing Nucleic Acids and Analogues: Challenges and Opportunities.Polymer chemistry · 2021Article
- Biomolecular Densely Grafted Brush Polymers: Oligonucleotides, Oligosaccharides and Oligopeptides.Angewandte Chemie (International ed. in English) · 2020Review
- Degradable Polyphosphoramidate via Ring-Opening Metathesis Polymerization.ACS macro letters · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Herein, we develop a facile route to bring DNA to the organic phase, which greatly expands the types of structures accessible using DNA macromonomers. Phosphotriester- and exocyclic amine-protected DNA was synthesized and further modified with a norbornene moiety, which enables homopolymerization via ring-opening metathesis to produce brush-type DNA graft polymers in high yields. Subsequent deprotection cleanly reveals the natural phosphodiester DNA. The method not only achieves high molecular weight DNA graft polymers but when carried out at low monomer:catalyst ratios, yields oligomers that can be further fractionated to molecularly pure, monodisperse entities with one through ten DNA strands per molecule. In addition, we demonstrate substantial simplification in the preparation of traditionally difficult DNA-containing structures, such as DNA/poly(ethylene glycol) diblock graft copolymers and DNA amphiphiles. We envision that the marriage of oligonucleotides with the vast range of organic-phase polymerizations will result in many new classes of materials with yet unknown properties.
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Registered trials
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