Evidence map›Paper›PMID 31903159›Full record

ArticleTheranostics2020

Loss of histone macroH2A1 in hepatocellular carcinoma cells promotes paracrine-mediated chemoresistance and CD4

Oriana Lo Re, Tommaso Mazza, Sebastiano Giallongo, Paola Sanna, Francesca Rappa, Tu Vinh Luong, Giovanni Li Volti, Adela Drovakova, Tania Roskams, Matthias Van Haele and 2 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 45 citations in OpenAlex.

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  11. CD25BMC cancer · 2024
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  16. Epigenetic remodelling in human hepatocellular carcinoma.Journal of experimental & clinical cancer research : CR · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 4 countries.

Oriana Lo ReInternational Clinical Research Center, St' Anne's University Hospital, Brno, Czech Republic.
Tommaso MazzaIRCCS Casa Sollievo della Sofferenza, Laboratory of Bioinformatics, San Giovanni Rotondo (FG), Italy.
Sebastiano GiallongoInternational Clinical Research Center, St' Anne's University Hospital, Brno, Czech Republic.
Paola SannaInternational Clinical Research Center, St' Anne's University Hospital, Brno, Czech Republic.
Francesca RappaDepartment of Experimental Biomedicine and Clinical Neurosciences, University of Palermo, Palermo, Italy.
Tu Vinh LuongDepartment of Histopathology, Royal Free London NHS Foundation Trust, London, United Kingdom.
Giovanni Li VoltiDepartment of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.
Adela DrovakovaInstitute of Biophysics, Academy of Sciences of the Czech Republic, Brno, Czech Republic.
Tania RoskamsTranslational Cell & Tissue Research Unit, Department of Imaging & Pathology, Katholieke Universiteit Leuven, Leuven, Belgium.
Matthias Van HaeleTranslational Cell & Tissue Research Unit, Department of Imaging & Pathology, Katholieke Universiteit Leuven, Leuven, Belgium.
Emmanuel TsochatzisUCL Institute for Liver and Digestive Health, Royal Free Hospital, London, United Kingdom.
Manlio VinciguerraInternational Clinical Research Center, St' Anne's University Hospital, Brno, Czech Republic.
KU Leuven · BESt. Anne's University Hospital Brno · CZUniversity College London · GBCasa Sollievo della Sofferenza · ITCzech Academy of Sciences · CZRoyal Free London NHS Foundation Trust · GBUniversity Hospital Brno · CZUniversity of Catania · ITUniversity of Palermo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Drug Resistance, NeoplasmParacrine CommunicationCarcinoma, HepatocellularCell Line, TumorForkhead Transcription FactorsGene Expression Regulation, NeoplasticGene Knockdown TechniquesGlycolysisHistonesHumansHyaluronan ReceptorsInterleukin-2 Receptor alpha SubunitLiver NeoplasmsMaleMetabolomicsMiddle AgedCD44 protein, humanForkhead Transcription FactorsFOXP3 protein, humanHistonesHyaluronan ReceptorsInterleukin-2 Receptor alpha SubunitmacroH2A histoneadaptive immune systemchemoresistance.hepatocellular carcinomahistone macroH2A1

Identifiers

PMID31903159
PMCPMC6929991
OpenAlexW2993935374

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.