Evidence map›Paper›PMID 31903142›Full record

ArticleTheranostics2020

Rod-shape theranostic nanoparticles facilitate antiretroviral drug biodistribution and activity in human immunodeficiency virus susceptible cells and tissues.

Bhavesh D Kevadiya, Brendan Ottemann, Insiya Z Mukadam, Laura Castellanos, Kristen Sikora, James R Hilaire, Jatin Machhi, Jonathan Herskovitz, Dhruvkumar Soni, Mahmudul Hasan and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Dual-Peak Lorentzian CEST MRI for antiretroviral drug brain distribution.NeuroImmune pharmacology and therapeutics · 2023
    Article
  8. Article
  9. Review
  10. Article
  11. Pharmacotherapeutics of SARS-CoV-2 Infections.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2021
    Review
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 1 country.

Bhavesh D KevadiyaDepartment of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, NE, USA.
Brendan OttemannDepartment of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, NE, USA.
Insiya Z MukadamDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, NE, USA.
Laura CastellanosDepartment of Chemistry, University of Massachusetts, Amherst, MA, USA.
Kristen SikoraDepartment of Chemistry, University of Massachusetts, Amherst, MA, USA.
James R HilaireDepartment of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, NE, USA.
Jatin MachhiDepartment of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, NE, USA.
Jonathan HerskovitzDepartment of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, NE, USA.
Dhruvkumar SoniDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, NE, USA.
Mahmudul HasanDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, NE, USA.
Wenting ZhangDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, NE, USA.
Sarella AnandakumarNebraska Center for Materials and Nanoscience, University of Nebraska-Lincoln, NE, USA.
Jered GarrisonDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, NE, USA.
JoEllyn McMillanDepartment of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, NE, USA.
Benson EdagwaDepartment of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, NE, USA.
R Lee MosleyDepartment of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, NE, USA.
Richard W VachetDepartment of Chemistry, University of Massachusetts, Amherst, MA, USA.
Howard E GendelmanDepartment of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, NE, USA.
University of Nebraska Medical Center · USUniversity of Massachusetts Amherst · USUniversity of Nebraska–Lincoln · US

Funding

Pharmacokinetics and Drug-Drug InteractionsP01DA028555 · NIDA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BOSKA, MICHAEL DOUGLAS · 2010 to 2019
$16.8M
CHEMISTRY-BIOLOGY INTERFACE PREDOCTORAL TRAINING GRANTST32GM008515 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI THOMPSON, LYNMARIE K. · 1995 to 2020
$4.3M
Combined Molecular Excision Therapy (CMET) for Eliminating HIV-1R01MH115860 · NIMH · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI GENDELMAN, HOWARD E · 2017 to 2021
$3.5M
Neuroimmunology of Disease Training ProgramT32NS105594 · NINDS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Aditya N Bade, Howard E Gendelman · 2018 to 2026
$1.4M
NIDA NIH HHS P01 DA028555NIGMS NIH HHS T32 GM008515NIMH NIH HHS R01 MH115860NINDS NIH HHS T32 NS105594
6 · The paper itself

Abstract

Human immunodeficiency virus theranostics facilitates the development of long acting (LA) antiretroviral drugs (ARVs) by defining drug-particle cell depots. Optimal drug formulations are made possible based on precise particle composition, structure, shape and size. Through the creation of rod-shaped particles of defined sizes reflective of native LA drugs, theranostic probes can be deployed to measure particle-cell and tissue biodistribution, antiretroviral activities and drug retention.

Indexed as

AnimalsCells, CulturedDrug Delivery SystemsHIV-1HIV InfectionsLutetiumMacrophagesMiceMice, Inbred BALB CNanoparticlesRadioisotopesRadiopharmaceuticalsReverse Transcriptase InhibitorsRilpivirineTheranostic NanomedicineTissue DistributionLutetiumLutetium-177RadioisotopesRadiopharmaceuticalsReverse Transcriptase InhibitorsRilpivirineDrug biodistributionLaser ablation inductively coupled plasma mass spectrometryLong acting antiretroviral therapyMultimodal imagingSingle photon emission computed tomography

Identifiers

PMID31903142
PMCPMC6929995
OpenAlexW2992518006

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.