Evidence map›Paper›PMID 31903138›Full record

ArticleTheranostics2020

Delivery of polymeric nanostars for molecular imaging and endoradiotherapy through the enhanced permeability and retention (EPR) effect.

Jeroen A C M Goos, Andrew Cho, Lukas M Carter, Thomas R Dilling, Maria Davydova, Komal Mandleywala, Simon Puttick, Abhishek Gupta, William S Price, John F Quinn and 3 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 2 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 88 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Linking In Vivo Imaging to Therapeutic Outcome withInternational journal of molecular sciences · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Hyaluronic acid-modified polymeric nanoplatform deliveringJournal of pharmaceutical analysis · 2026
    Article
  9. Review
  10. Tumor-Targeting TACS omega · 2025
    Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Jeroen A C M GoosDepartment of Radiology, Memorial Sloan-Kettering Cancer Center, New York, USA.
Andrew ChoDepartment of Biochemistry & Structural Biology, Weill Cornell Graduate School, New York, USA.
Lukas M CarterDepartment of Radiology, Memorial Sloan-Kettering Cancer Center, New York, USA.
Thomas R DillingDepartment of Radiology, Memorial Sloan-Kettering Cancer Center, New York, USA.
Maria DavydovaDepartment of Radiology, Memorial Sloan-Kettering Cancer Center, New York, USA.
Komal MandleywalaDepartment of Radiology, Memorial Sloan-Kettering Cancer Center, New York, USA.
Simon PuttickProbing Biosystems Future Science Platform, Commonwealth Scientific and Industrial Research Organisation, Herston, Australia.
Abhishek GuptaNanoscale Organisation and Dynamics Group, Western Sydney University, Penrith, Australia.
William S PriceNanoscale Organisation and Dynamics Group, Western Sydney University, Penrith, Australia.
John F QuinnARC Centre of Excellence in Convergent Bio-Nano Science & Technology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.
Michael R WhittakerARC Centre of Excellence in Convergent Bio-Nano Science & Technology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.
Jason S LewisDepartment of Radiology, Memorial Sloan-Kettering Cancer Center, New York, USA.
Thomas P DavisARC Centre of Excellence in Convergent Bio-Nano Science & Technology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.
Memorial Sloan Kettering Cancer Center · USMonash University · AUWestern Sydney University · AUHealth Sciences and Nutrition · AUTri-Institutional PhD Program in Chemical Biology · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Leveraging Pb-203/212 for the Theranostic Imaging and Therapy of Prostate CancerR35CA232130 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LEWIS, JASON S. · 2019 to 2025
$8.2M
NCI NIH HHS P30 CA008748NCI NIH HHS R35 CA232130
6 · The paper itself

Abstract

Expression levels of biomarkers are generally unknown at initial diagnosis. The development of theranostic probes that do not rely on biomarker availability would expand therapy options for cancer patients, improve patient selection for nanomedicine and facilitate treatment of inoperable patients or patients with acquired therapy resistance. Herein, we report the development of star polymers, also known as nanostars, that allow for molecular imaging and/or endoradiotherapy based on passive targeting

Indexed as

AnimalsCell Line, TumorColonic NeoplasmsHumansMiceMice, Inbred BALB CMice, NudeMolecular ImagingNanoparticlesPermeabilityPolymersPositron-Emission TomographyRadiopharmaceuticalsTheranostic NanomedicineTissue DistributionXenograft Model Antitumor AssaysPolymersRadiopharmaceuticalsEPR effectimagingnanoparticlestar polymertherapy

Identifiers

PMID31903138
PMCPMC6929988
OpenAlexW2992728507

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.