Evidence map›Paper›PMID 31903130›Full record

ReviewTheranostics2020

Type H blood vessels in bone modeling and remodeling.

Yi Peng, Song Wu, Yusheng Li, Janet L Crane

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Theranostics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 339 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
339citing papers in PubMed, 2 pooled it
15.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

339 citing papers in PubMed, 2 syntheses or guidelines pooled it, 546 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Review
  20. Review

279 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Yi PengDepartment of Orthopedic Surgery, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China.
Song WuDepartment of Orthopedic Surgery, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China.
Yusheng LiDepartment of Orthopedic Surgery, Xiangya Hospital of Central South University, Changsha, Hunan 410008, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan 41000, China.
Janet L CraneDepartment of Orthopedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Central South University · CNJohns Hopkins University · US

Funding

Temporal-spatial Regulation of MSCs by IGF-1K08AR064833 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI CRANE, JANET · 2014 to 2018
$650k
Angiogenic Potential in Children with Glucocorticoid-Induced OsteoporosisR03AR073939 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI CRANE, JANET · 2018 to 2019
$164k
NIAMS NIH HHS K08 AR064833NIAMS NIH HHS R03 AR073939
6 · The paper itself

Abstract

In the mammalian skeletal system, osteogenesis and angiogenesis are intimately linked during bone growth and regeneration in bone modeling and during bone homeostasis in bone remodeling. Recent studies have expanded our knowledge about the molecular and cellular mechanisms responsible for coupling angiogenesis and bone formation. Type H vessels, termed such because of high expression of Endomucin (Emcn) and CD31, have recently been identified and have the ability to induce bone formation. Factors including platelet-derived growth factor type BB (PDGF-BB), slit guidance ligand 3 (SLIT3), hypoxia-inducible factor 1-alpha (HIF-1α), Notch, and vascular endothelial growth factor (VEGF) are involved in the coupling of angiogenesis and osteogenesis. This review summarizes the current understanding of signaling pathways that regulate type H vessels and how type H vessels modulate osteogenesis. Further studies dissecting the regulation and function of type H vessels will provide new insights into the role of bone vasculature in the metabolism of the skeleton. We also discuss considerations for therapeutic approaches targeting type H vessels to promote fracture healing, prevent pathological bone loss, osteonecrosis, osteoarthritis, and bone metastases.

Indexed as

Bone RemodelingNeovascularization, PhysiologicOsteogenesisAnimalsBlood VesselsBone and BonesHumansPlatelet Endothelial Cell Adhesion Molecule-1SialoglycoproteinsEMCN protein, humanPECAM1 protein, humanPlatelet Endothelial Cell Adhesion Molecule-1SialoglycoproteinsAngiogenesisBone formationCD31hiEmcnhi endothelial cellsH-type vesselsOsteogenesisType H vessels

Identifiers

PMID31903130
PMCPMC6929606
OpenAlexW2985596826

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.