ArticleTheranostics2020
Macrophage MSR1 promotes BMSC osteogenic differentiation and M2-like polarization by activating PI3K/AKT/GSK3β/β-catenin pathway.
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Article in Theranostics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 177 papers.
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177citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
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Who cites it
177 citing papers in PubMed, 315 citations in OpenAlex.
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- M1 macrophage-derived CXCL12 drives neurogenic heterotopic ossification following spinal cord injury.Neural regeneration research · 2026Article
- 7,8-Dihydroxyflavone ameliorates bone loss by regulating TRKB/AKT/FOXO3a pathway in a mouse model of alzheimer's disease.Psychopharmacology · 2026Article
- Local administration of polymyxin B-conjugated Akkermansia muciniphila outer membrane vesicles attenuate asthma by suppressing M2 macrophage polarization.Science China. Life sciences · 2026Article
- [Isolation, purification and immunomodulatory activity of polysaccharide fromNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026Article
- Applications of DNA Hydrogels in Osteoporotic Bone Defects.Journal of functional biomaterials · 2026Review
- GLP-1 regulates osteo-adipogenic fate of BMSCs via HIF-2-AKT signaling and supports trabecular bone in glucocorticoid-induced osteoporosis.Stem cell reports · 2026Article
- Tri-modal nanocatalytic microenvironment regulations for macrophage reprogramming and osteoporotic fracture healing promotion.Materials today. Bio · 2026Article
- Macrophage Derived TGF-β Recruits BMSCs for Initiation of Bone Formation During Fracture Healing.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Ckb-Cryab-Drp1 axis enhances BMSC osteogenic differentiation and mouse alveolar bone healing through mitochondrial fission modulation.Stem cells translational medicine · 2026Article
- Microglia Attenuate Neuroinflammation After Subarachnoid Hemorrhage by Modulating Astrocyte Phenotypic Transformation via the RARα/Mafb/Msr1 Pathway.Molecular neurobiology · 2026Article
- Senescent BMSC-Derived Thbs1 Drives Inflammaging and Impairs Bone Regeneration by Suppressing PINK1/Parkin-Mediated Mitophagy in Macrophages.Aging cell · 2026Article
- An immunomodulatory bioactive glass orchestrates early bone healing via coordinated macrophage polarization and osteogenesis-osteolysis balance.Materials today. Bio · 2026Article
- HIRA promotes osteogenic differentiation of BMSCs and ameliorates osteoporosis by mediating M2 polarization of macrophages through the YAP1/β-catenin pathway.Molecular and cellular biochemistry · 2026Article
- Advances in the study of macrophage polarization in intervertebral disc degeneration.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Review
- Mechanical Force Promotes Mitochondrial Transfer From Macrophages to BMSCs to Enhance Bone Formation.Cell proliferation · 2026Article
- CD204 regulates microglial/macrophage M1/M2 polarization and alleviates neuroinflammation following intracerebral hemorrhage.Scientific reports · 2026Article
- Multifunctional bilayer scaffolds integrating melt electrowriting fibers and drug-loaded microspheres promote posteochondral regeneration through PI3K-AKT-mediated chondro-osteogenic signaling.Materials today. Bio · 2026Article
117 more citing papers are in PubMed but not listed here.
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Authors and funding
18 authors at 3 institutions in 1 country.
Shu-Jie ZhaoDepartment of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Fan-Qi KongDepartment of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Jian JieDepartment of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Qing LiState Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200240, China.
Hao LiuDepartment of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
An-Di XuKey Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, 211100, China.
Ya-Qing YangKey Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, 211100, China.
Bin JiangKey Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, 211100, China.
Dong-Dong WangKey Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, 211100, China.
Zhong-Qiu ZhouKey Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, 211100, China.
Peng-Yu TangDepartment of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Jian ChenDepartment of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Qian WangDepartment of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Zheng ZhouDepartment of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Qi ChenKey Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, 211100, China.
Guo-Yong YinDepartment of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Han-Wen ZhangKey Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, 211100, China.
Jin FanDepartment of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Nanjing Medical University · CNJiangsu Province Hospital · CNState Key Laboratory of Oncogene and Related Genes · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
Approximately 10% of bone fractures do not heal satisfactorily, leading to significant clinical and socioeconomic implications. Recently, the role of macrophages in regulating bone marrow stem cell (BMSC) differentiation through the osteogenic pathway during fracture healing has attracted much attention.
Indexed as
OsteogenesisSignal TransductionAnimalsbeta CateninCell DifferentiationMacrophagesMesenchymal Stem CellsMiceMice, Inbred C57BLMice, KnockoutPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRAW 264.7 CellsScavenger Receptors, Class Abeta CateninMsr1 protein, mousePhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktScavenger Receptors, Class ABone marrow stem cellsMacrophage scavenger receptor 1Osteogenic differentiationOxidative phosphorylationPI3K/AKT/GSK3β/β-catenin pathway
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.