Evidence map›Paper›PMID 31902985›Full record

ArticleBioinformation2019

Molecular modelling and docking analysis of pleurocidin (an antimicrobial peptide) like peptides with enterotoxin H from Klebsilla pneumonia.

Giridharan Bupesh, Manickam Sivaraman Nandini, Sakthivel Vasanth, Tharumasivam Siva Vijayakumar, Chinnaiah Amutha, Kaliyaperumal Prabhu, Vellingiri Balachnadar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioinformation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Giridharan BupeshResearch and Development Wing, Sree Balaji Medical College and Hospital, BIHER, Chrompet, Chennai 600044, India.
Manickam Sivaraman NandiniDepartment of Microbiology, Sree Balaji Medical College and Hospital, BIHER, Chrompet, Chennai600044, India.
Sakthivel VasanthResearch and Development Wing, Sree Balaji Medical College and Hospital, BIHER, Chrompet, Chennai 600044, India.
Tharumasivam Siva VijayakumarDepartment of Biotechnology, Srimad Andavan College, Tiruchirappalli, India.
Chinnaiah AmuthaDepartment of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli, India.
Kaliyaperumal PrabhuDepartment of Anatomy, Sree Balaji Medical College and Hospital, BIHER, Chrompet, Chennai-600044, India.
Vellingiri BalachnadarDepartment of Human genetics and molecular biology, Bharathiyar University, Coimbatore, Tamilnadu, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Enterotoxin H is a key molecular target for replication and establishment of Klebsilla pneumonia in the host. Therefore, it is of interest to study the interaction of enterotoxin H with pleurocidin like peptides using molecular modelling (template PDB ID: 1YCE), Lig-Plot (ligand construction) and docking tools for therapeutic consideration. The hydrophobic pocket and the active site residues (Val 13, Met 16, Gly 25, Ala 25, and Ile 28) were identified using Cast P, Molegro and Sitehound tools. Docking results show that the pleurocidin like peptides interacts with the active sites of enterotoxin H with 300.96 docking score with optimal binding features.

Indexed as

anti microbial peptidedockingEnterotoxin H proteinKlebsilla pneumoniamodelingpleurocidin

Identifiers

PMID31902985
PMCPMC6936665

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.