Evidence map›Paper›PMID 31902758›Full record

ArticleIEEE transactions on medical imaging2020

Quadratic Autoencoder (Q-AE) for Low-Dose CT Denoising.

Fenglei Fan, Hongming Shan, Mannudeep K Kalra, Ramandeep Singh, Guhan Qian, Matthew Getzin, Yueyang Teng, Juergen Hahn, Ge Wang

Abstract read
In one paragraph

Article in IEEE transactions on medical imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Supervision by Denoising.IEEE transactions on pattern analysis and machine intelligence · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Systematic Review on Learning-based Spectral CT.IEEE transactions on radiation and plasma medical sciences · 2024
    Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Fenglei Fan
Hongming Shan
Mannudeep K Kalra
Ramandeep Singh
Guhan Qian
Matthew Getzin
Yueyang Teng
Juergen Hahn
Ge Wang

Funding

Development and Validation of Prognostic Radiomic Markers of Response and Recurrence for Patients with Colorectal Liver MetastasesR01CA233888 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI CHUN, YUN SHIN, DO, RICHARD KINH GIAN · 2019 to 2023
$3.7M
Photon-counting X-ray and Optical Tomography for Preclinical Cancer ResearchR01CA237267 · NCI · RENSSELAER POLYTECHNIC INSTITUTE · PI BARROSO, MARGARIDA, INTES, XAVIER · 2019 to 2023
$2.9M
Life time imaging with pulsed x-ray based x-ray luminescence computed tomographyR01EB026646 · NIBIB · UNIVERSITY OF CALIFORNIA, MERCED · PI LI, CHANGQING · 2018 to 2021
$2.6M
NCI NIH HHS R01 CA233888NCI NIH HHS R01 CA237267NIBIB NIH HHS R01 EB026646
6 · The paper itself

Abstract

Inspired by complexity and diversity of biological neurons, our group proposed quadratic neurons by replacing the inner product in current artificial neurons with a quadratic operation on input data, thereby enhancing the capability of an individual neuron. Along this direction, we are motivated to evaluate the power of quadratic neurons in popular network architectures, simulating human-like learning in the form of "quadratic-neuron-based deep learning". Our prior theoretical studies have shown important merits of quadratic neurons and networks in representation, efficiency, and interpretability. In this paper, we use quadratic neurons to construct an encoder-decoder structure, referred as the quadratic autoencoder, and apply it to low-dose CT denoising. The experimental results on the Mayo low-dose CT dataset demonstrate the utility and robustness of quadratic autoencoder in terms of image denoising and model efficiency. To our best knowledge, this is the first time that the deep learning approach is implemented with a new type of neurons and demonstrates a significant potential in the medical imaging field.

Indexed as

NeuronsTomography, X-Ray ComputedHumans

Identifiers

PMID31902758
PMCPMC7376975

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.