Evidence map›Paper›PMID 31902726›Full record

ArticleCurrent biology : CB2020

Mechanotransduction-Dependent Control of Stereocilia Dimensions and Row Identity in Inner Hair Cells.

Jocelyn F Krey, Paroma Chatterjee, Rachel A Dumont, Mary O'Sullivan, Dongseok Choi, Jonathan E Bird, Peter G Barr-Gillespie

Open access · greenAbstract read
In one paragraph

Article in Current biology : CB, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
3.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 73 citations in OpenAlex.

  1. CaProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Hair cell loss - cause or consequence of hearing loss?Frontiers in cell and developmental biology · 2026
    Review
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  19. CIB2 and CIB3 Regulate Stereocilia Maintenance and Mechanoelectrical Transduction in Mouse Vestibular Hair Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Jocelyn F KreyOregon Hearing Research Center & Vollum Institute, Oregon Health & Science University, Portland, OR 97239, USA.
Paroma ChatterjeeOregon Hearing Research Center & Vollum Institute, Oregon Health & Science University, Portland, OR 97239, USA.
Rachel A DumontOregon Hearing Research Center & Vollum Institute, Oregon Health & Science University, Portland, OR 97239, USA.
Mary O'SullivanOtolaryngology-Head & Neck Surgery, Stanford School of Medicine, Palo Alto, CA 94304, USA.
Dongseok ChoiOHSU-PSU School of Public Health, Oregon Health & Science University, Portland, OR 97239, USA; Graduate School of Dentistry, Kyung Hee University, Seoul 02447, South Korea.
Jonathan E BirdDepartment of Pharmacology and Therapeutics, University of Florida, Gainesville, FL 32610, USA.
Peter G Barr-GillespieOregon Hearing Research Center & Vollum Institute, Oregon Health & Science University, Portland, OR 97239, USA; Oregon Hearing Research Center, Mail Code L335A, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA. Electronic address: gillespp@ohsu.edu.
Oregon Health & Science University · USVollum Institute · USStanford Medicine · USUniversity of Florida · US

Funding

Hair-Bundle ProteinsR01DC002368 · NIDCD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Peter Gordon Barr-Gillespie · 1994 to 2026
$11.3M
Ultrastructure and Single Particle Microscopy CoreP30NS061800 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI AICHER, SUE A · 2009 to 2020
$6.6M
Hair Bundle Structure and DynamicsR01DC011034 · NIDCD · OREGON HEALTH & SCIENCE UNIVERSITY · PI BARR-GILLESPIE, PETER GORDON · 2010 to 2024
$6.4M
Designing new aminoglycosides to alleviate inner ear toxicityR01DC014720 · NIDCD · STANFORD UNIVERSITY · PI CHENG, ALAN GI-LUN, RICCI, ANTHONY J · 2016 to 2020
$3.0M
Proteomic characterization of the mechanotransduction complex in hair cellsR03DC014544 · NIDCD · OREGON HEALTH & SCIENCE UNIVERSITY · PI KREY, JOCELYN F · 2015 to 2017
$462k
NIDCD NIH HHS R01 DC002368NIDCD NIH HHS R01 DC011034NIDCD NIH HHS R01 DC014720NIDCD NIH HHS R03 DC014544NINDS NIH HHS P30 NS061800
6 · The paper itself

Abstract

Actin-rich structures, like stereocilia and microvilli, are assembled with precise control of length, diameter, and relative spacing. By quantifying actin-core dimensions of stereocilia from phalloidin-labeled mouse cochleas, we demonstrated that inner hair cell stereocilia developed in specific stages, where a widening phase is sandwiched between two lengthening phases. Moreover, widening of the second-tallest stereocilia rank (row 2) occurred simultaneously with the appearance of mechanotransduction. Correspondingly, Tmc1

Indexed as

AnimalsFemaleHair Cells, Auditory, InnerMaleMechanotransduction, CellularMiceMice, Inbred C57BLStereociliaactinAiryscandevelopmenthair bundlehair cellsmechanotransductionmyosinstereocilia

Identifiers

PMID31902726
PMCPMC7002276
OpenAlexW2997799419

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.