ArticleJournal of the American Heart Association2020
Fontan-Associated Liver Disease: Spectrum of Disease in Children and Adolescents.
Article in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clinical predictors and noninvasive imaging in Fontan-associated liver disease: A systematic review and meta-analysis.Hepatology communications · 2024Pooled it
- Childhood Liver-Related Abnormalities After Fontan Completion: Evidence from a 20-Year Tertiary Centre Cohort.Pediatric cardiology · 2026Article
- Two-dimensional shear wave elastography in Fontan-associated liver disease: a narrative review.Abdominal radiology (New York) · 2026Review
- Transjugular Liver Biopsy in Children Undergoing Fontan Surgery: Safety and Comparison of Fibrosis Grade with Non-invasive Tests.Pediatric cardiology · 2026Article
- Prognostic biomarkers in Fontan associated liver disease.Translational pediatrics · 2026Review
- Long-term survival and complications of Fontan patients: where do we stand?American journal of cardiovascular disease · 2026Review
- Cytokeratin-18 is Elevated Prior to Conventional Measures of Liver Disease in Fontan-Associated Liver Disease.Pediatric cardiology · 2025Article
- Article
- Fontan-Associated Liver Disease.Seminars in liver disease · 2025Review
- Spleen shear wave elastography measurements do not correlate with histological grading of liver fibrosis in Fontan physiology: a preliminary investigation.Pediatric radiology · 2024Article
- Pediatric cirrhotic cardiomyopathy: literature review and effect size estimations of selected parameters.European journal of pediatrics · 2024Review
- Prognostic Indicators of Morbidity and Mortality in Children with Congestive Hepatopathy Presenting with Ascites.Diagnostics (Basel, Switzerland) · 2024Article
- Reliability of transient elastography as a noninvasive method for estimating central venous pressure in adult patients after a Fontan procedure.International journal of cardiology. Congenital heart disease · 2023Article
- Liver stiffness in Fontan patients: the effect of respiration and food intake.Frontiers in medicine · 2023Article
- Routine follow-up transjugular liver biopsy in Fontan patients: technical considerations and safety of an initial case series and literature review.Frontiers in pediatrics · 2023Article
- Fontan-associated liver disease: Diagnosis, surveillance, and management.Frontiers in pediatrics · 2023Review
- Care Pattern for Fontan-Associated Liver Disease by Academic Pediatric Hepatologists in Canada.JPGN reports · 2022Article
- Semiquantitative characterization of dynamic magnetic resonance perfusion of the liver in pediatric Fontan patients.Pediatric radiology · 2022Article
- Surveillance of Fontan-associated liver disease: current standards and a proposal from the European Society of Paediatric Radiology Abdominal Task Force.Pediatric radiology · 2021Article
- Congenital heart disease-associated liver disease: a narrative review.Cardiovascular diagnosis and therapy · 2021Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Information is evolving on liver disease in pediatric patients with Fontan physiology. The purpose of this investigation is to evaluate the spectrum of liver disease in a pediatric population of patients with Fontan physiology and evaluate transient elastography (TE) as a noninvasive marker of liver disease. Methods and Results We prospectively enrolled all children with Fontan physiology. All patients underwent comprehensive liver evaluation including liver enzymes (alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase, alkaline phosphatase), aspartate transaminase to platelet ratio index, albumin, bilirubin, international normalized ratio, complete blood cell count, abdominal ultrasound, and TE. Transjugular liver biopsies and hemodynamic measurements were performed in a subset of patients. A total of 76 children (median, 11.7; interquartile range, 8.4-14.8 [56% male]) were evaluated, with 17 having a transjugular liver biopsy (median 14.8 years; interquartile range, 14.3-17.4). All biopsies showed pathological changes. The severity of liver pathology did not correlate with TE. There was a positive correlation between TE and time since Fontan (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.