Evidence map›Paper›PMID 31902320›Full record

ArticleJournal of the American Heart Association2020

Renal Hydrogen Peroxide Production Prevents Salt-Sensitive Hypertension.

Santiago Cuevas, Laureano D Asico, Pedro A Jose, Prasad Konkalmatt

Open access · goldAbstract readComparative Study
In one paragraph

Article in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Stroke-prone salt-sensitive spontaneously hypertensive rats show higher susceptibility to spreading depolarization (SD) and altered hemodynamic responses to SD.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Article
  4. NFAT5 Is Involved in GRP-Enhanced Secretion of GLP-1 by Sodium.International journal of molecular sciences · 2021
    Article
  5. Article
  6. Review
  7. Renal Hydrogen Peroxide Production Prevents Salt-Sensitive Hypertension.Journal of the American Heart Association · 2020
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Santiago CuevasDivision of Renal Diseases & Hypertension Department of Medicine The George Washington University School of Medicine and Health Sciences Washington DC.
Laureano D AsicoDivision of Renal Diseases & Hypertension Department of Medicine The George Washington University School of Medicine and Health Sciences Washington DC.
Pedro A JoseDivision of Renal Diseases & Hypertension Department of Medicine The George Washington University School of Medicine and Health Sciences Washington DC.
Prasad KonkalmattDivision of Renal Diseases & Hypertension Department of Medicine The George Washington University School of Medicine and Health Sciences Washington DC.
George Washington University · US

Funding

Spatiotemporal transregulation of D1-like angiotensin receptors in genetically...P01HL074940 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI JOSE, PEDRO A. · 2004 to 2020
$31.8M
RENAL DOPAMINE-1 RECEPTOR DEFECT IN HYPERTENSIONR01DK039308 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI JOSE, PEDRO A. · 1987 to 2020
$7.4M
TRAINING IN CELLULAR PHYSIOLOGY MEMBRANE TRANSPORTT32DK007545 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GUTIERREZ, ORLANDO M · 1987 to 2023
$4.5M
Renal G Protein-Coupled Receptor 37L1 Regulates Blood PressureR56DK116828 · NIDDK · GEORGE WASHINGTON UNIVERSITY · PI KONKALMATT, PRASAD · 2018 to 2018
$100k
NHLBI NIH HHS P01 HL074940NIDDK NIH HHS R01 DK039308NIDDK NIH HHS R56 DK116828NIDDK NIH HHS T32 DK007545
6 · The paper itself

Abstract

Background The regulation of sodium excretion is important in the pathogenesis of hypertension and salt sensitivity is predictive of cardiovascular events and mortality. C57Bl/6 and BALB/c mice have different blood pressure sensitivities to salt intake. High salt intake increases blood pressure in some C57Bl/6J mouse strains but not in any BALB/c mouse strain. Methods and Results We determined the cause of the difference in salt sensitivity between C57Bl/6 and BALB/c mice. Basal levels of superoxide and H

Indexed as

Blood PressureOxidative StressSodium Chloride, DietaryAnimalsCatalaseCells, CulturedDisease Models, AnimalHydrogen PeroxideHypertensionKidney Tubules, ProximalMice, Inbred BALB CMice, Inbred C57BLRenal EliminationSpecies SpecificityCatalaseHydrogen PeroxideSodium Chloride, Dietarycatalasehydrogen peroxidehypertensionoxidative stresssalt‐sensitivity

Identifiers

PMID31902320
PMCPMC6988155
OpenAlexW2998677987

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.