ArticleGenes & genomics2020
Molecular evidence for adaptive evolution of olfactory-related genes in cervids.
Article in Genes & genomics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 3 citations in OpenAlex.
- Comparative Genomics Reveal Phylogenetic Relationship and Chromosomal Evolutionary Events of Eight Cervidae Species.Animals : an open access journal from MDPI · 2024Article
- Haplotype-resolved Genome of Sika Deer Reveals Allele-specific Gene Expression and Chromosome Evolution.Genomics, proteomics & bioinformatics · 2023Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCervids have evolved very successful means for survival and thriving to adapt to various climates and environments. One of these successful means might be the effective and efficient way of communication. To support this notion, cervids are well equipped with a variety of skin glands that distribute in different body regions. However, studies relevant to adaptive evolution in cervids, particularly on olfactory reception at the molecular level, have thus far not been reported.
objectiveTo provide valuable insights into molecular evidence for the adaptive evolution of olfactory-related gene in cervids.
methodsBased on recently sequenced genomes of cervids and closely-related-species, we performed comparative genomic analysis at genome level using bioinformatics tools.
resultsTree topology strongly supported that Bovidae was the sister group of Moschidae and both formed a branch that was then clustered with Cervidae. Expansion of heavy chain genes of the dynein family and 51 rapidly evolving genes could be associated with adaptation of cilia that serve as sensory organelles and act as cellular antennae. Based on the branch-site model test along the deer branch spanning 7-21 mammalian species, 14 deer olfactory receptor genes were found to be undergoing positive selection pressure and 89 positive selection sites (probability > 60%) had amino acid substitutions unique to deer.
conclusionThis study, for the first time, provides significant molecular evidence for adaption of olfactory-related genes of cervids according to their olfactory behavior.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.