Evidence map›Paper›PMID 31902035›Full record

ArticleDocumenta ophthalmologica. Advances in ophthalmology2020

ISCEV extended protocol for derivation and analysis of the strong flash rod-isolated ERG a-wave.

Mitchell Brigell, Brett G Jeffrey, Omar A Mahroo, Radouil Tzekov

Open access · hybridAbstract read
PubMed Publisher
In one paragraph

Article in Documenta ophthalmologica. Advances in ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. ISCEV and IPS guideline for the full-field stimulus test (FST).Documenta ophthalmologica. Advances in ophthalmology · 2024
    Guideline
  2. Article
  3. Review
  4. Article
  5. ISCEV standard for clinical visual evoked potentials (2025 update).Documenta ophthalmologica. Advances in ophthalmology · 2025
    Review
  6. Article
  7. Review
  8. Slope between positive and negative ERG components in patients with open-angle glaucoma.Documenta ophthalmologica. Advances in ophthalmology · 2024
    Article
  9. ISCEV standard for clinical pattern electroretinography (2024 update).Documenta ophthalmologica. Advances in ophthalmology · 2024
    Article
  10. Article
  11. Review
  12. Article
  13. Rod photoreceptor activation and deactivation in early-stage diabetic eye disease.Documenta ophthalmologica. Advances in ophthalmology · 2023
    Article
  14. Article
  15. ISCEV Standard for full-field clinical electroretinography (2022 update).Documenta ophthalmologica. Advances in ophthalmology · 2022
    Article
  16. Article
  17. Article
  18. ISCEV standard for clinical multifocal electroretinography (mfERG) (2021 update).Documenta ophthalmologica. Advances in ophthalmology · 2021
    Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 2 countries.

Mitchell BrigellAerpio Therapeutics, 9987 Carver Road, Suite 420, Cincinnati, OH, 45242, USA. mgbrigell@gmail.com.ORCID 0000-0001-8644-4945
Brett G JeffreyOphthalmic Genetics and Visual Function Branch, National Eye Institute, Bethesda, MD, USA.
Omar A MahrooMoorfields Eye Hospital, City Road, London, EC1V 2PD, UK.
Radouil TzekovDepartment of Ophthalmology, University of South Florida, Tampa, FL, 33612, USA.
Io Therapeutics (United States) · USMoorfields Eye Hospital NHS Foundation Trust · GBNational Eye Institute · USUniversity of South Florida · US

Funding

Wellcome Trust 206619/Z/17/Z
6 · The paper itself

Abstract

The International Society for the Clinical Electrophysiology of Vision (ISCEV) standard for full-field electroretinography (ERG) describes a minimum set of tests, but encourages the use of additional protocols for clinical ERG testing. This extended protocol describes recording methods and derivations that will allow analysis of rod-driven components of the dark-adapted (DA) strong flash ERG a-wave, more closely related to rod phototransduction than ISCEV standard DA ERGs. The method involves recording ERGs to a flash strength equivalent to 30 cd s m

Indexed as

ElectroretinographyPhotic StimulationClinical ProtocolsDark AdaptationElectrophysiologyHumansInternationalityLightRetinal Rod Photoreceptor CellsSocieties, MedicalVision, OcularClinical standardsElectroretinogram (ERG)Full-field ERGInternational Society for Clinical Electrophysiology of Vision (ISCEV)PhototransductionRod photoreceptors

Identifiers

PMID31902035
OpenAlexW2998334544

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.