Evidence map›Paper›PMID 31902023›Full record

ArticleThe European journal of health economics : HEPAC : health economics in prevention and care2020

A vision 'bolt-on' increases the responsiveness of EQ-5D: preliminary evidence from a study of cataract surgery.

Mihir Gandhi, Marcus Ang, Kelvin Teo, Chee Wai Wong, Yvonne Chung-Hsi Wei, Rachel Lee-Yin Tan, Mathieu F Janssen, Nan Luo

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Article in The European journal of health economics : HEPAC : health economics in prevention and care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Assessing Quality of life of Patients with Cataract and Glaucoma using Generic and Vision-Specific Instruments in India.Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine · 2026
    Article
  3. Testing culturally relevant EQ-5D-5L bolt-ons for the Chinese general population: first quantitative phase of a mixed methods study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026
    Article
  4. Article
  5. Identifying and developing culturally relevant EQ-5D-5L bolt-on items for Chinese population: qualitative phase of a mixed-methods study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025
    Article
  6. Psychometric testing of two respiratory bolt-on items to EQ-5D-5L in patients with obstructive airway diseases.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025
    Article
  7. Article
  8. Testing four cognition bolt-on items to the EQ-5D in a general Chinese population.The European journal of health economics : HEPAC : health economics in prevention and care · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Content validity of the EQ-5D-5L with skin irritation and self-confidence bolt-ons in patients with atopic dermatitis: a qualitative think-aloud study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024
    Article
  14. Comparison of three health-related quality of life instruments in relation to visual acuity: EQ-5D, 15D, and EUROHIS-QOL8.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023
    Article
  15. Article
  16. Article
  17. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mihir GandhiDepartment of Biostatistics, Singapore Clinical Research Institute, #02-01, 31 Biopolis Way, Singapore, Singapore.ORCID http://orcid.org/0000-0002-8902-2710
Marcus AngDepartment of Ophthalmology, Singapore National Eye Centre, 11 Third Hospital Ave, Singapore, Singapore.ORCID http://orcid.org/0000-0003-3022-0795
Kelvin TeoDepartment of Ophthalmology, Singapore National Eye Centre, 11 Third Hospital Ave, Singapore, Singapore.ORCID http://orcid.org/0000-0002-7458-7081
Chee Wai WongDepartment of Ophthalmology, Singapore National Eye Centre, 11 Third Hospital Ave, Singapore, Singapore.ORCID http://orcid.org/0000-0002-0935-2016
Yvonne Chung-Hsi WeiDepartment of Ophthalmology, Singapore National Eye Centre, 11 Third Hospital Ave, Singapore, Singapore.ORCID http://orcid.org/0000-0002-5515-4029
Rachel Lee-Yin TanSaw Swee Hock School of Public Health, National University of Singapore, 12 Science Drive 2, Singapore, Singapore.ORCID http://orcid.org/0000-0002-4610-1195
Mathieu F JanssenSection Medical Psychology and Psychotherapy, Department of Psychiatry, Erasmus MC, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0001-6602-6949
Nan LuoSaw Swee Hock School of Public Health, National University of Singapore, 12 Science Drive 2, Singapore, Singapore. ephln@nus.edu.sg.ORCID http://orcid.org/0000-0001-7980-6979

Funding

EuroQol Research Foundation EQ Project 2016310
6 · The paper itself

Abstract

objectives(1) To evaluate the effect of adding a vision dimension ('bolt-on') to the 5-level EQ-5D (EQ-5D-5L) and 3-level EQ-5D (EQ-5D-3L) on their responsiveness, and (2) to compare the responsiveness of a vision 'bolt-on' EQ-5D-3L (EQ-5D-3L + V) with SF-6D and Health Utilities Index Mark 3 (HUI3) to the benefit of cataract surgery.

methodsSixty-three patients were assessed before and after their cataract surgery using the EQ-5D-3L, EQ-5D-5L, SF-6D, HUI3, as well as a 3-level and a 5-level vision dimension. Preference-based indices were calculated using available value sets for EQ-5D-3L, EQ-5D-3L + V, EQ-5D-5L, SF-6D, and HUI3, and non-preference-based indices were calculated using the sum-score method for EQ-5D-5L and EQ-5D-5L + V (vision bolt-on EQ-5D-5L). Responsiveness was assessed using the standardized response mean (SRM) and F-statistic.

resultsAmong preference-based indices, mean changes from pre to post-surgery in EQ-5D-3L + V and EQ-5D-3L indices were 0.031 and 0.018, respectively. The mean changes for EQ-5D-5L, SF-6D and HUI3 indices were 0.020, 0.012 and 0.105, respectively. The SRM (F-statistic) for EQ-5D-3L + V and EQ-5D-3L indices were 0.458 (13.2) and 0.098 (0.6), respectively. The responsiveness of EQ-5D-3L + V was better than EQ-5D-5L, SF-6D; the responsiveness of HUI3 was better than all other measures. Using non-preference-based indices, mean change for EQ-5D-5L + V and EQ-5D-5L were 0.067 and 0.017, respectively. The corresponding SRM (F-statistic) were 0.709 (31.7) and 0.295 (5.4).

conclusionsPreliminary evidence from our study suggests that a vision 'bolt-on' may increase the responsiveness of EQ-5D-3L and EQ-5D-5L to change in health outcomes experienced by patients undergoing cataract surgery. In absence of the preference-based vision bolt-on EQ-5D-5L index, HUI3 was the most responsive measure.

Indexed as

Patient PreferenceVisual AcuityAgedCataract ExtractionCost-Benefit AnalysisFemaleHealth StatusHumansLongitudinal StudiesMaleMiddle AgedMorpholinesProspective StudiesPsychometricsQuality of LifeReproducibility of ResultsMorpholinesRE 102Bolt-onCataractEQ-5DResponsivenessVision

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.