ArticleSchizophrenia bulletin2020
Differences in Functional Connectivity Networks Related to the Midbrain Dopaminergic System-Related Area in Various Psychiatric Disorders.
Article in Schizophrenia bulletin, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Aberrant salience is selectively associated with ventral midbrain connectivity to the dorsal but not ventral striatum.Schizophrenia (Heidelberg, Germany) · 2026Article
- Gut microbiota modulates synaptic plasticity, connectivity, and dopamine transmission in the VTA-mPFC pathway in bipolar depression.Molecular psychiatry · 2026Article
- Sexual Dimorphism in Levodopa-Induced Dyskinesia Following Parkinson's Disease: Uncharted Territory.The European journal of neuroscience · 2025Review
- Abnormal Functional Connectivity Pattern of the Reward Circuitry Is Associated with Negative Symptoms and Cognitive Functions in First-Episode Schizophrenia.Psychiatry and clinical psychopharmacology · 2025Article
- Advances and Challenges in Depression Marker Research.Neuropsychiatric disease and treatment · 2025Review
- Human Brain Magnetic Resonance Imaging Studies for Psychiatric Disorders: The Current Progress and Future Directions.JMA journal · 2024Review
- Alterations in subcortical magnetic susceptibility and disease-specific relationship with brain volume in major depressive disorder and schizophrenia.Translational psychiatry · 2024Article
- Distinctive alterations in the mesocorticolimbic circuits in various psychiatric disorders.Psychiatry and clinical neurosciences · 2023Article
- Connectivity alterations of mesostriatal pathways in first episode psychosis.Schizophrenia (Heidelberg, Germany) · 2023Article
- Structural brain abnormalities in schizophrenia patients with a history and presence of auditory verbal hallucination.Translational psychiatry · 2022Article
- Recent Advances and Future Directions in Brain MR Imaging Studies in Schizophrenia: Toward Elucidating Brain Pathology and Developing Clinical Tools.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2022Article
- Magnetic resonance imaging of the dopamine system in schizophrenia - A scoping review.Frontiers in psychiatry · 2022Article
- Mood disorders disrupt the functional dynamics, not spatial organization of brain resting state networks.NeuroImage. Clinical · 2021Article
- Article
- Increased Functional Coupling between VTA and Hippocampus during Rest in First-Episode Psychosis.eNeuroArticle
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveDisruptions in the dopamine system have been observed in psychiatric disorders. Since dopamine is mainly produced in the ventral tegmental area (VTA), elucidating the differences in the VTA neural network across psychiatric disorders would facilitate a greater understanding of the pathophysiological mechanisms underlying these disorders. However, no study has compared VTA-seed-based functional connectivity across psychiatric disorders. Therefore, we conducted a resting-state functional magnetic resonance imaging (rs-fMRI) study to perform a seed-based fMRI analysis, using the VTA as a seed.
methodsWe included participants with major depressive disorder (MDD; n = 45), schizophrenia (n = 32), and bipolar disorder (BPD; n = 30), along with healthy control participants (n = 46) who were matched for age, gender, and handedness.
resultsThe results showed that patients with MDD and BPD had altered VTA-related connectivity in the superior frontal gyrus, frontal pole regions, hippocampus, cerebellum, and posterior cingulate cortex. Some of these differences in connectivity were also found between affective disorders and schizophrenia; however, there were no differences between the schizophrenia and control groups. Connectivity between the VTA and the hippocampus was correlated with positive symptoms in the schizophrenia group. The connectivity was not associated with medication dose, and the results remained significant after controlling for dose.
conclusionsThe results suggest that altered brain functional connectivity related to VTA networks could be associated with the distinctive pathophysiologies of psychiatric disorders, especially affective disorders.
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