ReviewEuropean journal of obstetrics, gynecology, and reproductive biology2020
Bacterial vaginosis-A brief synopsis of the literature.
Review in European journal of obstetrics, gynecology, and reproductive biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05652959 (Real-world Performance and Safety of Cerviron® Medical Device in the Treatment of Various Types of Vaginitis), which is not on this map. Cited by 122 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Real-world Performance and Safety of Cerviron® Medical Device in the Treatment of Various Types of Vaginitis
Who cites it
122 citing papers in PubMed, 7 syntheses or guidelines pooled it, 283 citations in OpenAlex.
- Risk of HSV-2 Acquisition Among Women with Bacterial Vaginosis: Systematic Review and Meta-Analysis.Viruses · 2026Pooled it
- Tinidazole vs metronidazole for the treatment of bacterial vaginosis: a systematic review and meta-analysis.Archives of gynecology and obstetrics · 2025Pooled it
- Systematic review and meta-analysis of the global prevalence and infection risk factors of Trichomonas vaginalis.Parasite (Paris, France) · 2025Pooled it
- Efficacy and safety of different drugs for the treatment of bacterial vaginosis: a systematic review and network meta-analysis.Frontiers in cellular and infection microbiology · 2024Pooled it
- Probiotics are a good choice for the treatment of bacterial vaginosis: a meta-analysis of randomized controlled trial.Reproductive health · 2022Pooled it
- Probiotics, a promising therapy to reduce the recurrence of bacterial vaginosis in women? a systematic review and meta-analysis of randomized controlled trials.Frontiers in nutrition · 2022Pooled it
- Non-antibiotic treatment of bacterial vaginosis-a systematic review.Archives of gynecology and obstetrics · 2021Pooled it
- Adjunct vaginal lactic acid with single-dose metronidazole for bacterial vaginosis: a randomized controlled trial.BMC women's health · 2026Trial
- Probiotics reduce the recurrence of asymptomatic bacterial vaginosis in Chinese women.Scientific reports · 2025Trial
- Effectiveness and tolerability of lactic acid vaginal gel compared to oral metronidazole in the treatment of acute symptomatic bacterial vaginosis: a multicenter, randomized-controlled, head-to-head pilot study.BMC women's health · 2025Trial
- Effect of Cymbopogon olivieri-based herbal vaginal product on bacterial vaginosis.Revista da Associacao Medica Brasileira (1992) · 2024Trial
- Lactobacillus Vaginal Tablets in Preventing Recurrence of Bacterial Vaginosis: A Systematic Review and Meta-Analysis.Probiotics and antimicrobial proteins · 2026Review
- The proteinaceous biofilm ofBiofilm · 2026Article
- Quantitative determination of vaginal diamines as a biomarker for vaginal dysbiosis and IVF-ET outcome.Reproductive biology and endocrinology : RB&E · 2026Article
- Epidemiology and management of bacterial vaginosis in Dakar, Senegal.BMC women's health · 2026Observational
- Bacterial Load ofMicroorganisms · 2026Article
- The vaginal microbiome in pregnancy and preterm birth: mechanisms, disparities, and therapeutic opportunities.NPJ biofilms and microbiomes · 2026Review
- Review
- Ligand-binding properties of substrate binding proteins of a maltose uptake system inMicrobiology (Reading, England) · 2026Article
- Microbiota Transplantation as a Future Novel Therapeutic Strategy Approach.Diseases (Basel, Switzerland) · 2026Review
62 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Bacterial vaginosis (BV) affects women of reproductive age and can either be symptomatic or asymptomatic. Approximately 50 % of women are symptomatic and experience vaginal malodor, discharge, itching and increased vaginal pH. BV can increase the risk of contracting many sexually transmitted infections (STIs) such as human immunodeficiency virus (HIV), Neisseria gonorrhea (NG), Chlamydia trachomatis (CT), Trichomonas vaginalis (TV) and herpes simplex virus-2 (HSV-2). Though effective treatment options do exist, metronidazole or clindamycin, these methods have proven not to be effective long term. The purpose of this review is to summarize current literature on the epidemiology of BV and highlight areas of deficiency in current clinical practice with respect to BV. BV recurrence rates are high, approximately 80 % three months after effective treatment. Furthermore, in some instances treatment is ineffective and BV persists. Literature also documents the relationship between BV and human papillomavirus (HPV). HPV is the most common sexually transmitted infection among young adult women while BV is the most common cause of vaginal symptoms among women of reproductive age. BV is associated with high levels of anaerobic organisms which can damage the vaginal epithelium and increase the risk of HPV infection. Recent research also highlights the role of the vaginal microbiome in BV. The results of this review warrant further exploration into the etiology of BV as well as exploration of more long-term effective treatment and the investigation of prognostic indicators. Additionally, the need for a standard definition of recurrent and persistent BV is recognized.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.