Evidence map›Paper›PMID 31901639›Full record

ArticleThe Journal of surgical research2020

Venous Mechanical Properties After Arteriovenous Fistulae in Mice.

Kirstyn E Brownson, Ramak Khosravi, Shin-Rong Lee, Kimberly Goldstein, Toshihiko Isaji, Shun Ono, Clinton D Protack, Jay D Humphrey, Alan Dardik

Open access · greenAbstract read
In one paragraph

Article in The Journal of surgical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Sustained tenascin-C expression drives neointimal hyperplasia and promotes aortocaval fistula failure.American journal of physiology. Heart and circulatory physiology · 2025
    Article
  2. Hemodynamics and Wall Mechanics of Vascular Graft Failure.Arteriosclerosis, thrombosis, and vascular biology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Kirstyn E BrownsonVascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut; Department of Surgery, Yale University School of Medicine, New Haven, Connecticut.
Ramak KhosraviDepartment of Biomedical Engineering, Yale University School of Engineering, New Haven, Connecticut.
Shin-Rong LeeVascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut; Department of Surgery, Yale University School of Medicine, New Haven, Connecticut.
Kimberly GoldsteinDepartment of Biomedical Engineering, Yale University School of Engineering, New Haven, Connecticut.
Toshihiko IsajiVascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut; Department of Surgery, Yale University School of Medicine, New Haven, Connecticut.
Shun OnoVascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut; Department of Surgery, Yale University School of Medicine, New Haven, Connecticut.
Clinton D ProtackVascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut; Department of Surgery, Yale University School of Medicine, New Haven, Connecticut.
Jay D HumphreyVascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut; Department of Biomedical Engineering, Yale University School of Engineering, New Haven, Connecticut.
Alan DardikVascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut; Department of Surgery, Yale University School of Medicine, New Haven, Connecticut; Department of Surgery, VA Connecticut Healthcare Systems, West Haven, Connecticut. Electronic address: alan.dardik@yale.edu.
Yale University · US

Funding

Manipulating the matrix to improve arteriovenous fistula patencyR01HL144476 · NHLBI · YALE UNIVERSITY · PI Alan Dardik · 2019 to 2026
$5.6M
Molecular Regulation of Vein Graft AdapationR01HL095498 · NHLBI · YALE UNIVERSITY · PI DARDIK, ALAN · 2009 to 2013
$2.4M
Enhancing venous adaptation to the arterial environmentR01HL128406 · NHLBI · YALE UNIVERSITY · PI DARDIK, ALAN · 2016 to 2019
$1.9M
Molecular regulation of vein graft adaptationR56HL095498 · NHLBI · YALE UNIVERSITY · PI DARDIK, ALAN · 2014 to 2014
$416k
Molecular regulation of fistula adaptation for dialysis accessI01BX002336 · VA · VA CONNECTICUT HEALTHCARE SYSTEM · PI DARDIK, ALAN · 2014 to 2017
–
BLRD VA I01 BX002336NHLBI NIH HHS R01 HL095498NHLBI NIH HHS R01 HL128406NHLBI NIH HHS R01 HL144476NHLBI NIH HHS R56 HL095498
6 · The paper itself

Abstract

backgroundAn arteriovenous fistula (AVF) exposes the outflow vein to arterial magnitudes and frequencies of blood pressure and flow, triggering molecular pathways that result in venous remodeling and AVF maturation. It is unknown, however, how venous remodeling, that is lumen dilation and wall thickening, affects venous mechanical properties. We hypothesized that a fistula is more compliant compared with a vein because of altered contributions of collagen and elastin to the mechanical properties.

methodsEphb4

resultsMechanical testing of the thoracic inferior vena cava from Ephb4

conclusionsFistula-induced remodeling of the outflow vein results in circumferentially increased distensibility and compliance, likely due to post-translational modifications to collagen.

Indexed as

Arteriovenous Shunt, SurgicalAnimalsCollagenElasticityElastinMaleMice, Inbred C57BLReceptor, EphB4Vena Cava, InferiorCollagenElastinEphb4 protein, mouseReceptor, EphB4Arteriovenous fistulaCollagenComplianceElastinEphB4StiffnessVenous remodeling

Identifiers

PMID31901639
PMCPMC7054128
OpenAlexW2997711421

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.