ArticlePsychoneuroendocrinology2020
Testosterone replacement causes dose-dependent improvements in spatial memory among aged male rats.
Article in Psychoneuroendocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Chronic estrogen supplementation in the aging castrated male rat is not associated with renal injury or activation of the renin angiotensin system.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- Local synthesis and function of neuro-estrogen and neuro-androgen: impact on the hippocampus-related cognition and neuronal plasticity.Frontiers in cellular neuroscience · 2025Review
- Testosterone reduces hippocampal synaptic damage in an androgen receptor-independent manner.The Journal of endocrinology · 2024Article
- Exercise Associated with Cognitive Function in Older Men with Prostate Cancer Undergoing Androgen Deprivation Therapy.International journal of behavioral medicine · 2023Article
- Genetic and Epigenetic Sexual Dimorphism of Brain Cells during Aging.Brain sciences · 2023Review
- Impact of Testosterone on Alzheimer's Disease.The world journal of men's health · 2022Review
- Effects of Long-Acting Testosterone Undecanoate on Behavioral Parameters and Na + , KNeurochemical research · 2021Article
- Dose-dependent effects of testosterone on spatial learning strategies and brain-derived neurotrophic factor in male rats.Psychoneuroendocrinology · 2020Article
- Testosterone and Adult Neurogenesis.Biomolecules · 2020Review
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Testosterone has been shown to have dose-dependent effects on spatial memory in males, but the effects of aging upon this relationship remain unclear. Additionally, the mechanism by which testosterone regulates memory is unknown, but may involve changes in brain-derived neurotrophic factor (BDNF) within specific brain regions. We tested the effects of age and testosterone on spatial memory among male rats using two spatial memory tasks: an object-location memory task (OLMT) and the radial-arm maze (RAM). Castration had minimal effect on performance on the RAM, but young rats (2 months) performed significantly fewer working memory errors than aged rats (20 months), and aged rats performed significantly fewer reference memory errors. Both age and castration impaired performance on the OLMT, with only the young rats with intact gonads successfully performing the task. Subsequent experiments involved daily injections of either drug vehicle or one of four doses of testosterone propionate (0.125, 0.250, 0.500, and 1.00 mg/rat) given to castrated aged males. On the RAM, a low physiological dose (0.125 mg) and high doses (0.500-1.000 mg) of testosterone improved working memory, while an intermediate dose (0.250 mg) did not. On the OLMT, only the 0.250 mg T group showed a significant increase in exploration ratios from the exposure trials to the testing trials, indicating that this group remembered the position of the objects. Brain tissue (prefrontal cortex, hippocampus, and striatum) was collected from all subjects to assay BDNF. We found no evidence that testosterone influenced BDNF, indicating that it is unlikely that testosterone regulates spatial memory through changes in BDNF levels.
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