ArticleInsect biochemistry and molecular biology2020
Nix is a male-determining factor in the Asian tiger mosquito Aedes albopictus.
Article in Insect biochemistry and molecular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 52 citations in OpenAlex.
- Neoclassical development of genetic sexing strains for insect pest and disease vector control.Insect science · 2026Review
- Emerging trends in genome editing of wild animals.Transgenic research · 2026Review
- Mosquito sex determination: recent advances and applications.Current opinion in insect science · 2025Review
- Insights on the sex determination, vector capacity and ecological biology from a chromosomal level genome of vector mosquito, Armigeres subulbatus.Infectious diseases of poverty · 2025Article
- The odorant-binding protein genes obp67 and obp56d-like encode products that guide oviposition site selection in the Asian tiger mosquito, Aedes albopictus.Insect science · 2025Article
- Understanding the genetics of sex determination in insects and its relevance to genetic pest management.Insect molecular biology · 2025Review
- Generation of Cas9 Knock-InDNA · 2025Article
- CRISPR-editing of the virus vectorMethodsX · 2024Article
- Vision guides the twilight search for oviposition sites of the Asian tiger mosquito, Aedes albopictus.PLoS neglected tropical diseases · 2024Article
- Gustatory receptor 11 is involved in detecting the oviposition water of Asian tiger mosquito, Aedes albopictus.Parasites & vectors · 2024Article
- Hybridization between Aedes aegypti and Aedes mascarensis mosquitoes leads to disruption of male sex determination.Communications biology · 2024Article
- On the Origin and Evolution of the Mosquito Male-determining Factor Nix.Molecular biology and evolution · 2024Article
- A DBHS family member regulates male determination in the filariasis vector Armigeres subalbatus.Nature communications · 2023Article
- Optimized In Vitro CRISPR/Cas9 Gene Editing Tool in the West Nile Virus Mosquito Vector,Insects · 2022Article
- Selective targeting of biting females to control mosquito-borne infectious diseases.Trends in parasitology · 2022Review
- Natural and Engineered Sex Ratio Distortion in Insects.Frontiers in ecology and evolution · 2022Article
- The AalNix3&4 isoform is required and sufficient to convert Aedes albopictus females into males.PLoS genetics · 2022Article
- Interspecific mating bias may drivePNAS nexus · 2022Article
- Cellular diversity and gene expression profiles in the male and female brain of Aedes aegypti.BMC genomics · 2022Article
- Flavivirus-host interactions: an expanding network of proviral and antiviral factors.Current opinion in virology · 2022Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
The initial signal that governs sex determination is highly variable among insects. A homolog of Nix, the male-determining factor in Aedes aegypti, was previously found in the Asian tiger mosquito Ae. albopictus. Here we show that the Ae. albopictus Nix (AalNix) is more complex in gene structure and splice isoforms than its Ae. aegypti homolog (AaeNix). AalNix shows a similar transcription profile compared to AaeNix. CRISPR/Cas9-mediated knockouts of AalNix in vivo and in the Ae. albopictus C6/36 cells lead to a shift of dsx and fru splicing towards the female isoforms. G
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