ArticleCell stem cell2020
Outer Radial Glia-like Cancer Stem Cells Contribute to Heterogeneity of Glioblastoma.
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Article in Cell stem cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 241 papers.
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241citing papers in PubMed
33.2field-weighted citation impact, top 1% of its field
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241 citing papers in PubMed, 413 citations in OpenAlex.
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- Spatial and single-cell characterization of human glioblastoma tumor microenvironment reveals malignant cellular communities.Nature neuroscience · 2026Article
- Organoids to Model Tumor Microenvironment in Progression of Pathogenesis and Treatment Resistance in Glioblastoma Multiforme.Brain sciences · 2026Review
- Glutamatergic neuron-tumor synapses shape human glioblastoma cell states through radial glia plasticity.bioRxiv : the preprint server for biology · 2026Article
181 more citing papers are in PubMed but not listed here.
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Authors and funding
22 authors at 1 institution in 1 country.
Aparna BhaduriDepartment of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA; The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA.
Elizabeth Di LulloDepartment of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA; The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA.
Diane JungDepartment of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA; The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA.
Sören MüllerDepartment of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.
Elizabeth Erin CrouchDepartment of Pediatrics, University of California, San Francisco, San Francisco, CA 94143, USA.
Carmen Sandoval EspinosaDepartment of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA; The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA.
Tomoko OzawaDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.
Beatriz AlvaradoDepartment of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA; The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA.
Julien SpatazzaThe Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.
Cathryn René CadwellDepartment of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.
Grace WilkinsDepartment of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA; The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA.
Dmitry VelmeshevDepartment of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA; The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA.
Siyuan John LiuThe Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.
Martina MalatestaThe Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.
Madeline Gail AndrewsDepartment of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA; The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA.
Mohammed Andres Mostajo-RadjiDepartment of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA; The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA.
Eric Jinsheng HuangDepartment of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.
Tomasz Jan NowakowskiDepartment of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Anatomy, University of California, San Francisco, San Francisco, CA 94158, USA.
Daniel Amos LimThe Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.
Aaron DiazDepartment of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.
David Ronan RaleighDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: david.raleigh@ucsf.edu.
Arnold Richard KriegsteinDepartment of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA; The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: arnold.kriegstein@ucsf.edu.
University of California, San Francisco · US
Funding
Tissue CoreP50CA097257 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joseph F Costello · 2002 to 2026
$57.4MPediatric Scientist Development Program (PSDP) [K12]K12HD000850 · NICHD · YALE UNIVERSITY · PI Sallie R. Permar · 1987 to 2026
$44.1MResearch BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRUMMEL, MATTHEW F · 2003 to 2019
$21.8MDevelopment and Expansion of the Human Cerebral CortexR35NS097305 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRIEGSTEIN, ARNOLD · 2017 to 2024
$8.5MLong noncoding RNA regulation of neural stem cellsR01NS091544 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LIM, DANIEL A · 2016 to 2020
$1.7MUnderstanding How Ciliary Hedgehog Signaling Causes MedulloblastomaK08CA212279 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RALEIGH, DAVID R · 2017 to 2021
$886kUsing Single-Cell RNA Sequencing to Characterize Regional Differences in Cortical DevelopmentF32NS103266 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BHADURI, APARNA · 2017 to 2018
$108kRole of MLL Chromatin Remodeling Factor in Neural Stem CellsI01BX000252 · VA · VETERANS AFFAIRS MED CTR SAN FRANCISCO · PI DANIEL A LIM · 2009 to 2026
–NCI NIH HHS K08 CA212279NCI NIH HHS P50 CA097257NICHD NIH HHS K12 HD000850NIDDK NIH HHS P30 DK063720NINDS NIH HHS F32 NS103266NINDS NIH HHS R01 NS091544NINDS NIH HHS R35 NS097305
Abstract
Glioblastoma is a devastating form of brain cancer. To identify aspects of tumor heterogeneity that may illuminate drivers of tumor invasion, we created a glioblastoma tumor cell atlas with single-cell transcriptomics of cancer cells mapped onto a reference framework of the developing and adult human brain. We find that multiple GSC subtypes exist within a single tumor. Within these GSCs, we identify an invasive cell population similar to outer radial glia (oRG), a fetal cell type that expands the stem cell niche in normal human cortex. Using live time-lapse imaging of primary resected tumors, we discover that tumor-derived oRG-like cells undergo characteristic mitotic somal translocation behavior previously only observed in human development, suggesting a reactivation of developmental programs. In addition, we show that PTPRZ1 mediates both mitotic somal translocation and glioblastoma tumor invasion. These data suggest that the presence of heterogeneous GSCs may underlie glioblastoma's rapid progression and invasion.
Indexed as
Brain NeoplasmsGlioblastomaAdultCell Line, TumorEpendymoglial CellsHumansNeoplastic Stem CellsReceptor-Like Protein Tyrosine Phosphatases, Class 5PTPRZ1 protein, humanReceptor-Like Protein Tyrosine Phosphatases, Class 5cancer stem cellglioblastomaouter radial gliasingle-cell sequencingtumor heterogeneity
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.