ArticleJournal of clinical laboratory analysis2020
Role of hematological parameters in the diagnosis of influenza virus infection in patients with respiratory tract infection symptoms.
Article in Journal of clinical laboratory analysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.
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Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The Impact of Neutrophil-Lymphocyte Count Ratio in COVID-19: A Systematic Review and Meta-Analysis.Journal of intensive care medicine · 2022Pooled it
- The neutrophil to lymphocyte ratio is an independent predictor for severe COVID-19 : Evidence from a multicenter case-control study and meta-analyses.Wiener klinische Wochenschrift · 2021Pooled it
- The diagnostic and prognostic role of neutrophil-to-lymphocyte ratio in COVID-19: a systematic review and meta-analysis.Expert review of molecular diagnostics · 2021Pooled it
- Longitudinal transcriptional analysis of peripheral blood leukocytes in COVID-19 convalescent donors.Journal of translational medicine · 2022Trial
- Epidemiology of viral and atypical bacterial respiratory infections among children hospitalised at a Kenyan tertiary referral centre: a cross sectional multiplex PCR study.Frontiers in pediatrics · 2026Article
- Prediction of influenza virus infection based on deep learning and peripheral blood proteomics: A diagnostic study.Journal of advanced research · 2026Article
- Seasonal Distribution of Viral Pneumonia After COVID-19 and the Role of Hematological Markers in Assessing Pneumonia Severity: A Case-Control Study.Tropical medicine and infectious disease · 2025Article
- Clinical and Paraclinical Peculiarities of SARS-CoV-2 and Influenza Infections in Children: A Comparative Study.Life (Basel, Switzerland) · 2025Article
- Bronchiolitis Severity Affects Blood Count and Inflammatory Marker Levels: A Real-Life Experience.Viruses · 2025Article
- Mendelian randomization study highlights the role of hematological traits on Type-2 diabetes mellitus in African ancestry individuals.Frontiers in pharmacology · 2025Article
- Influenza and Aging: Clinical Manifestations, Complications, and Treatment Approaches in Older Adults.Drugs & aging · 2025Review
- Article
- Clinical characteristics and prognostic factors of pulmonary and extrapulmonary cryptococcosis.BMC infectious diseases · 2024Article
- Predictive factors for COVID-19 severity and mortality in hospitalized children.BMC infectious diseases · 2024Article
- Altered counts and mitochondrial mass of peripheral blood leucocytes in patients with chronic hepatitis B virus infection.Journal of cellular and molecular medicine · 2024Article
- Prediction of hospital-acquired influenza using machine learning algorithms: a comparative study.BMC infectious diseases · 2024Observational
- Risk factors for hospitalization and pneumonia development of pediatric patients with seasonal influenza during February-April 2023.Frontiers in public health · 2023Article
- Preliminary Study of sCD14 and sCD163 as Predictors of Disease Severity and ICU Admission in COVID-19: Relation to Hematological Parameters, Blood Morphological Changes and Inflammatory Biomarkers.Mediterranean journal of hematology and infectious diseases · 2023Article
- Predicting Influenza A Virus Infection in the Lung from Hematological Data with Machine Learning.mSystems · 2022Article
- Could serum thrombocyte/lymphocyte (TLR), neutrophil/lymphocyte (NLR) and neutrophil/albumin (NAR) ratios be indicators of hospitalization and mortality in COVID-19?Iranian journal of microbiology · 2022Article
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Abstract
backgroundThe differential diagnoses of patients hospitalized for respiratory infections due to influenza virus vs other pathogens are challenging. Our study investigated whether hematological parameters such as neutrophil (N), lymphocyte (L), platelet (PLT), and neutrophil-to-lymphocyte ratio (NLR) contributed in diagnosing influenza virus infections and in discriminating other respiratory infections.
methodsWe retrospectively analyzed the laboratory characteristics of 307 patients with respiratory infections caused by influenza/non-influenza virus and bacteria. The diagnostic abilities of hematological indexes were evaluated in the patients compared with 100 healthy people.
resultsThe hematological parameters in patients with influenza virus infection were dramatically altered compared with those in the controls. Additionally, among the systemic inflammatory markers, the sensitivity of NLR for influenza detection was higher than that of N and L. PLT was significantly lower in influenza virus-positive infection than in influenza virus-negative infection. Moreover, when patients with influenza virus infection were cured, PLT returned to a normal level. The red blood cell (RBC) and hemoglobin (Hb) levels of influenza virus infection were higher than those of bacterial infection. Compared with traditional N and L, NLR and platelet-to-neutrophil (PNR) showed greater significance between influenza virus and bacterial infection (P < .01).
conclusionNeutrophil-to-lymphocyte ratio with high sensitivity is a preferable diagnostic tool to screen influenza virus-infected patients than N and L. PLT accounts in the differential diagnoses of respiratory infections due to influenza virus and other pathogens among patients. In addition, RBC, Hb, NLR, and PNR can significantly differentiate between influenza virus infections and bacterial infections.
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