ArticleCNS neuroscience & therapeutics2020
Microstructural disruption of the right inferior fronto-occipital and inferior longitudinal fasciculus contributes to WMH-related cognitive impairment.
Article in CNS neuroscience & therapeutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 1 of them a synthesis that pooled it.
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Who cites it
67 citing papers in PubMed, 1 synthesis or guideline pooled it, 108 citations in OpenAlex.
- Diffusion tensor imaging indices as biomarkers for cognitive changes following paediatric radiotherapy: a systematic review and meta-analysis.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2022Pooled it
- Multimodal MRI assessment of cerebral small vessel disease-related brain injury in the context of unilateral severe carotid artery stenosis.Neuroradiology · 2026Article
- [White matter microstructural disturbance and its relationship with cognitive function in schizophrenia with comorbidity of metabolic syndrome].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2026Article
- Silent yet impaired: Hidden memory processing deficits in asymptomatic individuals with moderate-to-severe white matter hyperintensities.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Associations of local white matter geometry with network efficiency, macrostructural abnormalities, and clinical severity in behavioural variant frontotemporal dementia.Brain communications · 2026Article
- White Matter Microstructural Injury in Patients With Acute Single Subcortical Infarction: A Preliminary Tract-Based Spatial Statistics With Atlas-Based Analysis.Neural plasticity · 2026Article
- Subtype-Specific Brain Atrophy and White Matter Alterations in Mild Cognitive Impairment.Brain sciences · 2025Article
- Brain White Matter Changes in Non-demented Individuals with Color Discrimination Deficits and Their Association with Cognitive Impairment: A NODDI Study.Neuroscience bulletin · 2025Article
- Damage to white matter networks resulting from small vessel disease and the effects on cognitive function.Scientific reports · 2025Article
- Deep adaptive learning predicts and diagnoses CSVD-related cognitive decline using radiomics from TNPJ digital medicine · 2025Article
- Alterations in microarchitecture and network integrity in diffusion tensor images of children with marginal intelligence or intellectual disabilities.Neuroradiology · 2025Article
- A multimodal MRI-based machine learning framework for classifying cognitive impairment in cerebral small vessel disease.Scientific reports · 2025Article
- Brain functional and structural alteration following acute carbon monoxide poisoning contribute to delayed neurological sequelae.Scientific reports · 2025Article
- Mapping the impact of age and APOE risk factors for late onset Alzheimer's disease on long range brain connections through multiscale bundle analysis.Brain structure & function · 2025Article
- Long-term effects of simulated microgravity in the central nervous system of rhesus monkeys: a voxel-wise multimodal MRI study.Frontiers in physiology · 2025Article
- Alterations of White Matter Microstructure in Primary Aldosteronism Patients With Normal Cognitive Functioning Using Diffusion Tensor Imaging.International journal of general medicine · 2025Article
- Clinical implications of sagittal stratum damage: Laterality, neuroanatomical developmental considerations, and functional outcomes.Surgical neurology international · 2025Review
- Article
- Connectome gradient dysfunction contributes to white matter hyperintensity-related cognitive decline.CNS neuroscience & therapeutics · 2024Article
- Mapping the impact of age and APOE risk factors for late onset Alzheimer's disease on long range brain connections through multiscale bundle analysis.bioRxiv : the preprint server for biology · 2024Article
7 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsWhite matter hyperintensity (WMH) is the most common neuroimaging manifestation of cerebral small vessel disease and is related to cognitive dysfunction or dementia. This study aimed to investigate the mechanism and effective indicators to predict WMH-related cognitive impairment.
methodsWe recruited 22 healthy controls (HC), 25 cases of WMH with normal cognition (WMH-NC), and 23 cases of WMH with mild cognitive impairment (WMH-MCI). All individuals underwent diffusion tensor imaging (DTI) and a standardized neuropsychological assessment. Automated Fiber Quantification was used to extract altered DTI metrics between groups, and partial correlation was performed to assess the associations between WM integrity and cognitive performance. Furthermore, machine learning analyses were performed to determine underlying imaging markers of WMH-related cognitive impairment.
resultsOur study found that mean diffusivity (MD) values of several fiber bundles including the bilateral anterior thalamic radiation (ATR), the left inferior fronto-occipital fasciculus (IFOF), the right inferior longitudinal fasciculus (ILF), and the right superior longitudinal fasciculus (SLF) were negatively correlated with memory function, while that of the anterior component of the right IFOF and the posterior and intermediate component of the right ILF showed significant negative correlation with MMSE and episodic memory, respectively. Furthermore, machine learning analyses showed that the accuracy of recognizing WMH-MCI patients from the WMH populations was up to 80.5% and the intermediate and posterior components of the right ILF and the anterior component of the right IFOF contribute the most.
conclusionsChanges in the properties of DTI may be the potential mechanism of WMH-related MCI, especially the right IFOF and the right ILF, which may become imaging markers for predicting WMH-related cognitive dysfunction.
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