Evidence map›Paper›PMID 31901081›Full record

ArticleNature communications2020

Gastric squamous-columnar junction contains a large pool of cancer-prone immature osteopontin responsive Lgr5

Dah-Jiun Fu, Lianghai Wang, Fouad K Chouairi, Ian M Rose, Danysh A Abetov, Andrew D Miller, Robert J Yamulla, John C Schimenti, Andrea Flesken-Nikitin, Alexander Yu Nikitin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Dah-Jiun FuDepartment of Biomedical Sciences and Cornell Stem Cell Program, Cornell University, Ithaca, NY, 14853, USA.
Lianghai WangDepartment of Biomedical Sciences and Cornell Stem Cell Program, Cornell University, Ithaca, NY, 14853, USA.
Fouad K ChouairiDepartment of Biomedical Sciences and Cornell Stem Cell Program, Cornell University, Ithaca, NY, 14853, USA.
Ian M RoseDepartment of Biomedical Sciences and Cornell Stem Cell Program, Cornell University, Ithaca, NY, 14853, USA.
Danysh A AbetovDepartment of Biomedical Sciences and Cornell Stem Cell Program, Cornell University, Ithaca, NY, 14853, USA.
Andrew D MillerDepartment of Biomedical Sciences and Cornell Stem Cell Program, Cornell University, Ithaca, NY, 14853, USA.ORCID http://orcid.org/0000-0001-6350-5581
Robert J YamullaDepartment of Biomedical Sciences and Cornell Stem Cell Program, Cornell University, Ithaca, NY, 14853, USA.
John C SchimentiDepartment of Biomedical Sciences and Cornell Stem Cell Program, Cornell University, Ithaca, NY, 14853, USA.
Andrea Flesken-NikitinDepartment of Biomedical Sciences and Cornell Stem Cell Program, Cornell University, Ithaca, NY, 14853, USA.ORCID http://orcid.org/0000-0003-3017-1399
Alexander Yu NikitinDepartment of Biomedical Sciences and Cornell Stem Cell Program, Cornell University, Ithaca, NY, 14853, USA. an58@cornell.edu.ORCID http://orcid.org/0000-0002-3729-7982
Cornell University · USShihezi University · CN

Funding

Origins of Ovarian CarcinomaR01CA182413 · NCI · CORNELL UNIVERSITY · PI NIKITIN, ALEXANDER Y. · 2015 to 2019
$1.8M
Neuroendocrine mechanisms of prostate cancer progressionR01CA197160 · NCI · CORNELL UNIVERSITY · PI NIKITIN, ALEXANDER Y. · 2015 to 2020
$1.8M
Research and Career Training in Vertebrate Developmental GenomicsT32HD057854 · NICHD · CORNELL UNIVERSITY · PI SCHIMENTI, JOHN C · 2010 to 2020
$1.3M
NCI NIH HHS R01 CA182413NCI NIH HHS R01 CA197160NICHD NIH HHS T32 HD057854
6 · The paper itself

Abstract

Areas of a junction between two types of epithelia are known to be cancer-prone in many organ systems. However, mechanisms for preferential malignant transformation at the junction areas remain insufficiently elucidated. Here we report that inactivation of tumor suppressor genes Trp53 and Rb1 in the gastric squamous-columnar junction (SCJ) epithelium results in preferential formation of metastatic poorly differentiated neoplasms, which are similar to human gastroesophageal carcinoma. Unlike transformation-resistant antral cells, SCJ cells contain a highly proliferative pool of immature Lgr5

Indexed as

AgedAged, 80 and overAnimalsCarcinoma, Squamous CellCell Transformation, NeoplasticCohort StudiesEsophagogastric JunctionFemaleHumansHyaluronan ReceptorsMaleMiceMice, KnockoutMiddle AgedOsteopontinReceptors, G-Protein-CoupledHyaluronan ReceptorsLgr5 protein, mouseOsteopontinReceptors, G-Protein-CoupledRetinoblastoma ProteinTumor Suppressor Protein p53

Identifiers

PMID31901081
PMCPMC6941991
OpenAlexW2996911776

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.