Evidence map›Paper›PMID 31900889›Full record

ArticleBrain imaging and behavior2020

Functional human brain connectivity during labor and its alteration under epidural analgesia.

Fan-Pei Yang, An-Shine Chao, Sung-Han Lin, Anne Chao, Tzu-Hao Wang, Yao-Lung Chang, Hong-Shiu Chang, Jiun-Jie Wang

Abstract read
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In one paragraph

Article in Brain imaging and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Fan-Pei YangDepartment of Foreign Languages and Literature, National Tsing Hua University, Hsinchu, Taiwan.
An-Shine ChaoDepartment of Obstetrics and Gynecology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan City, Taiwan.
Sung-Han LinDepartment of Medical Imaging and Radiological Sciences, Chang Gung University, 259 WenHua 1st Road, TaoYuan county, Taiwan.
Anne ChaoDepartment of Anesthesia, National Taiwan University Hospital, Taipei, Taiwan.
Tzu-Hao WangDepartment of Obstetrics and Gynecology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan City, Taiwan.
Yao-Lung ChangDepartment of Obstetrics and Gynecology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan City, Taiwan.
Hong-Shiu ChangDepartment of Neurology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan City, Taiwan.
Jiun-Jie WangDepartment of Medical Imaging and Radiological Sciences, Chang Gung University, 259 WenHua 1st Road, TaoYuan county, Taiwan. jwang@mail.cgu.edu.tw.ORCID http://orcid.org/0000-0002-2422-9059
Chang Gung University · TWChang Gung University of Science and Technology · TWNational Tsing Hua University · TW

Funding

Chang Gung Memorial Hospital, Linkou CMRPD1C0291-3Chang Gung Memorial Hospital, Linkou CMRPD1G0561-2Chang Gung Memorial Hospital, Linkou CMRPD3D0011-3Chang Gung Memorial Hospital, Linkou CMRPG2B0251Chang Gung Memorial Hospital, Linkou CMRPG 371631Chang Gung Memorial Hospital, Linkou CMRPG 371632Chang Gung University EMRPD1H0411Chang Gung University EMRPD1H0431Chang Gung University EMRPD1H0551Ministry of Science and Technology, Taiwan MOST 106-2314-B-182 -018 -MY3Ministry of Science and Technology, Taiwan NMRP 96-2314-B-182A-071
6 · The paper itself

Abstract

This study used functional magnetic resonance imaging to explore the neural networks of pain during labor and its relief. It was hypothesized that epidural analgesia would affect the neural activities and the underlying network connectivity. Analysis using dynamic causal modelling and functional connectivity was performed to investigate the spatial activity and network connection of labor pain with and without epidural analgesia. This Institutional Review Board approved study acquired Magnetic Resonance Imaging from 15 healthy women of spontaneous normal delivery (with/without epidural analgesia = 7/8, aged 29.6 ± 2.3 and 29.3 ± 4.8 years old respectively) using a 1.5 Tesla scanner. Numerical rating score of pain was evaluated by a research nurse in the beginning of the first stage of labor and approximately 30 min after imaging examination. Six regions of interested from the activated clusters and literature were selected for dynamic causal modelling, which included primary and secondary somatosensory cortex, middle frontal gyrus, anterior cingulate cortex, insula and lentiform. Functional connectivity was calculated from selected sensory and affective regions. All analyses were performed by using software of statistical parametric mapping version 8 and CONN functional connectivity toolbox. The result showed that the experience of labor pain can lead to activations within a distributed brain network. The pain relief from epidural analgesia can be accompanied with altered functional connectivity, which was most evident in the cingulo-frontal system. The present study, therefore, provides an overview of a pain-related neural network that occur during labor and upon epidural analgesia.

Indexed as

Analgesia, EpiduralAdultAnalgesia, ObstetricalBrainFemaleHumansMagnetic Resonance ImagingPain MeasurementPregnancyConnectivity networksDynamic causal modellingEpidural analgesiaFunctional magnetic resonance imagingLabor painNormal delivery

Identifiers

PMID31900889
OpenAlexW2997834249

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.