Observational studyJapanese journal of ophthalmology2020
Comparisons of photopic negative responses elicited by different conditions from glaucomatous eyes.
Observational study in Japanese journal of ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- The luminance-response function of the photopic negative response (PhNR): analysing different stimulation, recording and measurement approaches.Documenta ophthalmologica. Advances in ophthalmology · 2026Article
- The diagnostic accuracy of photopic negative responses evoked by broadband and chromatic stimuli in a clinically heterogeneous population.Documenta ophthalmologica. Advances in ophthalmology · 2023Article
- Intereye structure-function relationship using photopic negative response in patients with glaucoma or glaucoma suspect.Scientific reports · 2022Article
- Correlation Between Optical Coherence Tomography and Photopic Negative Response of Flash Electroretinography in Ganglion Cell Complex Assessment in Glaucoma Patients.Clinical ophthalmology (Auckland, N.Z.) · 2022Article
- Prediction of glaucoma severity using parameters from the electroretinogram.Scientific reports · 2021Article
- Asymmetric Functional Impairment of ON and OFF Retinal Pathways in Glaucoma.Ophthalmology science · 2021Article
- Photopic negative response using a handheld mini-ganzfeld stimulator in healthy adults: normative values, intra- and inter-session variability.Documenta ophthalmologica. Advances in ophthalmology · 2021Article
- The influence of mild cataract on ISCEV standard electroretinogram recorded from mydriatic eyes.Documenta ophthalmologica. Advances in ophthalmology · 2021Article
- Probing ON and OFF Retinal Pathways in Glaucoma Using Electroretinography.Translational vision science & technology · 2020Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
purposeTo compare the clinical significance of the photopic negative response (PhNRs) elicited by different stimuli from glaucomatous eyes. STUDY
designSingle-center observational study
methodEighty-four eyes of 84 patients with open angle glaucoma (OAG) and 40 eyes of 40 normal subjects were studied. Cone electroretinograms (ERGs) were elicited by white stimuli on a white background (W/W) or red stimuli on a blue background (R/B). The luminance of the stimuli was 0.5, 1.0, 2.0 or 3.0 cd-s/m
resultsThe correlation coefficients of the amplitudes of the PhNR1 elicited by W/W stimuli to the MDs and cpRNFL thickness were generally stronger, and the regression lines steeper than for the amplitudes of the PhNR1 elicited by R/B stimuli. In contrast, the correlation coefficients of the amplitudes of the PhNR2 elicited by R/B stimuli to the MDs and cpRNFL thickness were generally stronger, and the regression lines were steeper than the amplitudes of the PhNR2 elicited by W/W stimuli. With both types of stimuli, the slopes of the regression lines became steeper when the ERG recorded with higher stimulus intensities. The AUCs were significantly larger for the PhNR2 elicited by the R/B stimuli at 3.0 cd-s/m
conclusionThe PhNR1 and PhNR2 elicited by the W/W and R/B stimuli are suitable measures to assess the function of the RGCs in eyes with OAG. The PhNR2 elicited by R/B stimuli at higher stimulus intensities is most effective in detecting functional and structural changes of the RGCs with the highest diagnostic capacity in discriminating advanced glaucoma.
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