ArticleJournal of neuro-oncology2020
Impact of postoperative radiotherapy on recurrence of primary intracranial atypical meningiomas.
Article in Journal of neuro-oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Role of adjuvant radiotherapy in atypical (WHO grade II) and anaplastic (WHO grade III) meningiomas: a systematic review.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2021Pooled it
- Postoperative Adjuvant Radiotherapy in Atypical Meningioma Patients: A Meta-Analysis Study.Frontiers in oncology · 2021Pooled it
- Multisession radiosurgery for grade 2 (WHO), high risk meningiomas. A phase II clinical trial.Journal of neuro-oncology · 2022Trial
- Outcomes of Radiotherapy for WHO Grade 2 Meningioma: Survival, Local Control, and Prognostic Factors.Medicina (Kaunas, Lithuania) · 2026Article
- Outcomes of early versus late radiotherapy in grade 2 meningiomas: a National retrospective analysis from the TROD neuro-oncology group.Journal of neuro-oncology · 2026Article
- Fractionated radiotherapy adjuvant to surgery of WHO-2 meningioma with and without gross total resection: a multicenter, retrospective cohort study of 1,452 patients.Journal of neuro-oncology · 2026Article
- High-resolution detection of copy number alterations in single cells with HiScanner.Nature communications · 2025Article
- High-resolution detection of copy number alterations in single cells with HiScanner.bioRxiv : the preprint server for biology · 2025Article
- Initial management of newly diagnosed WHO grade 2-3 adult meningioma following surgery: results from the Dutch Brain Tumour Registry (2016-2021).Journal of neuro-oncology · 2024Article
- Impact on natural history of atypical meningioma after changes in 2016 edition of the world health organization (WHO) classification of central nervous system tumors: a literature review.Neurosurgical review · 2024Review
- A case of multiples liver metastases from a grade 2 brain meningioma: a rare entity with comprehensive literature review.Annals of medicine and surgery (2012) · 2024Article
- Grading meningioma resections: the Simpson classification and beyond.Acta neurochirurgica · 2024Review
- Multi-parameter MRI radiomic features may contribute to predict progression-free survival in patients with WHO grade II meningiomas.Frontiers in oncology · 2024Article
- Rethinking the effects of adjuvant beam radiation therapy on overall survival in atypical meningioma patients: age considerations.Frontiers in neurology · 2024Article
- Atypical meningiomas with multiple extracranial metastases: a case description.Quantitative imaging in medicine and surgery · 2023Article
- Review
- Radiotherapy for meningiomas.Journal of neuro-oncology · 2022Review
- Radiation therapy for atypical and anaplastic meningiomas: an overview of current results and controversial issues.Neurosurgical review · 2022Review
- Combining FORGE Score and Histopathological Diagnostic Criteria of Atypical Meningioma Enables Risk Stratification of Tumor Progression.Diagnostics (Basel, Switzerland) · 2021Article
- Establishment and Validation of an Integrated Model to Predict Postoperative Recurrence in Patients With Atypical Meningioma.Frontiers in oncology · 2021Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAtypical meningiomas (WHO grade II) have high recurrence rate. However, data on the effect of radiotherapy (RT) is still conflicting. The aim of this study was to evaluate the influence of postoperative RT on the recurrence of primary atypical intracranial meningiomas.
methodsThe medical records of all patients who underwent surgery (2007-2017 in 4 neurosurgical departments) for a histologically diagnosed primary atypical meningioma were reviewed to assess progression-free survival (PFS) and prognostic factors.
resultsThis analysis included 258 patients with a median age of 60 years (54.7% female). The predominant tumor locations were convexity and falx (60.9%) followed by the skull base (37.2%). Simpson grade I-II resection was achieved in 194 (75.2%) patients, Simpson grade III-IV in 53 patients (20.5%). Tumor progressed in 54 cases (20.9%). Postoperative RT was performed in 46 cases (17.8%). RT was more often applied after incomplete resection (37.7% vs. 13.4% Simpson III-IV vs. I-II). A multivariate analysis showed a significantly shorter PFS associated with Simpson III-IV [HR 1.19, (95% CI) 1.09-1.29, p < 0.001] and age > 65 years [HR 2.89, (95% CI) 1.56-5.33, p = 0.001]. A subgroup analysis with a minimal follow-up of 36 months revealed that Simpson III-IV [HR 3.01, 95% CI 1.31-6.931.03-1.24, p = 0.009] and age > 65 years [HR 2.48, 95% CI 1.20-5.13, p = 0.014] reduced PFS. The impact of postoperative RT on PFS remained statistically insignificant, even in a propensity-score matched survival analysis [n = 46; p = 0.438; OR 0.710 (0.299-1.687)].
conclusionsIn the present study, postoperative RT did not improve PFS. The most important prognostic factors remain the extent of resection and age.
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