ArticleDocumenta ophthalmologica. Advances in ophthalmology2020
Electroretinographic abnormalities associated with pregabalin: a case report.
Article in Documenta ophthalmologica. Advances in ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 20 citations in OpenAlex.
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- Can the long term using of pregabalin in fibromyalgia affect the choroid and retinal nerve fiber layer?Eye (London, England) · 2022Article
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- Homozygous single nucleotide duplication of SLC38A8 in autosomal recessive foveal hypoplasia: The first Japanese case report.Documenta ophthalmologica. Advances in ophthalmology · 2021Article
- Transient electroretinographic abnormalities that mimic those of KCNV2 retinopathy: a case report.Documenta ophthalmologica. Advances in ophthalmology · 2021Article
- Vitamin A deficiency after prolonged intake of an unbalanced diet in a Japanese hemodialysis patient.Documenta ophthalmologica. Advances in ophthalmology · 2021Article
- A new PDE6A missense variant p.Arg544Gln in rod-cone dystrophy.Documenta ophthalmologica. Advances in ophthalmology · 2021Article
- Genotype-Phenotype Correlations inJournal of clinical medicine · 2021Article
- Novel biallelic TRPM1 variants in an elderly patient with complete congenital stationary night blindness.Documenta ophthalmologica. Advances in ophthalmology · 2021Article
- Novel biallelic splice-site BBS1 variants in Bardet-Biedle syndrome: a case report of the first Japanese patient.Documenta ophthalmologica. Advances in ophthalmology · 2020Article
- Effects of medications on the human electroretinogram: A comprehensive review.Survey of ophthalmologyReview
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8 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
purposePregabalin binds to the α2-δ1/α2-δ2 subunits of the voltage-gated L-type calcium channel (LTCC), which is expressed in rod/cone photoreceptor terminals. The purpose of this report was to describe electroretinographic abnormalities associated with pregabalin treatment. CASE PRESENTATION: This is an observational case report. A 49-year-old female reported photophobia and night blindness in her left eye after 10 months of pregabalin administration. One month after the symptoms, ophthalmic examinations were performed, which revealed good visual acuity and no remarkable fundus findings. However, full-field electroretinography (ERG) of the left eye revealed a decreased b-wave in rod ERG, a slightly decreased a-wave and severely decreased b-wave (negative ERG) in bright flash ERG, decreased a- and b-waves in cone ERG, and decreased b-waves in 30-Hz flicker ERG. These findings are similar to those seen in incomplete congenital stationary night blindness, whereas the right eye ERG showed normal responses, except for a square a-wave in cone ERG. The ERG gradually improved from 1 to 12 months after discontinuing pregabalin. Finally, b-waves in bright flash ERG and cone ERG responses largely recovered, but b-waves in rod ERG and a-waves in bright flash ERG only partially recovered in the left eye. The square a-wave recovered to normal in the right eye.
conclusionsThis is the first report to indicate that ERG abnormalities might be associated with pregabalin treatment. Our results suggest that pregabalin may affect LTCC function via the α2-δ1/α2-δ2 subunits, which leads to defective synaptic transmission from rod/cone photoreceptors to bipolar cells.
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