Evidence map›Paper›PMID 31900677›Full record

ArticleJournal of pharmacokinetics and pharmacodynamics2020

The non-compartmental steady-state volume of distribution revisited.

Wojciech Jawień, Jan Kobierski

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of pharmacokinetics and pharmacodynamics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Wojciech JawieńDepartment of Pharmaceutical Biophysics, Jagiellonian University Medical College, ul. Medyczna 9, 30-688, Kraków, Poland. wojciech.jawien@uj.edu.pl.ORCID 0000-0002-1741-490X
Jan KobierskiDepartment of Pharmaceutical Biophysics, Jagiellonian University Medical College, ul. Medyczna 9, 30-688, Kraków, Poland.ORCID 0000-0003-3223-0014

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The lack in the literature of a simple, yet general and complete derivation of the widely used equation for non-compartmental calculation of steady-state volume of distribution is pointed out. It is demonstrated that the most frequently cited references contain an overly simplified explanation. The logical gap consists in doubly defining the same quantities without a proof the definitions are equivalent. Two alternative solutions are proposed: analytical derivation and hydrodynamic analogy. It is shown, that the problem can be analyzed in a purely macroscopic framework by utilizing the integral mean value of the function, without the need to resort to statistical distributions.

Indexed as

Models, BiologicalHumansHydrodynamicsIntegral mean value of the functionLinear pharmacokineticsMean residence timeNon-compartmental analysisSteady-state volume of distribution

Identifiers

PMID31900677

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.