Evidence map›Paper›PMID 31900648›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2020

Multifocal electroretinography in amblyopia.

Christiane Al-Haddad, Alaa Bou Ghannam, Zeinab El Moussawi, Elza Rachid, Karine Ismail, Marwan Atallah, Larissa Smeets, Hasan Chahine

Abstract read
PubMed Publisher
In one paragraph

Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

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  8. Reply to the letter to the editor: Multifocal electroretinography in amblyopia.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020
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  9. Comment on the article: multifocal electroretinography in amblyopia.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Christiane Al-HaddadOphthalmology Department, American University of Beirut Medical Center, PO Box 110236, Beirut, Lebanon. ca12@aub.edu.lb.ORCID http://orcid.org/0000-0001-7136-6278
Alaa Bou GhannamOphthalmology Department, American University of Beirut Medical Center, PO Box 110236, Beirut, Lebanon.
Zeinab El MoussawiOphthalmology Department, American University of Beirut Medical Center, PO Box 110236, Beirut, Lebanon.
Elza RachidOphthalmology Department, American University of Beirut Medical Center, PO Box 110236, Beirut, Lebanon.
Karine IsmailOphthalmology Department, American University of Beirut Medical Center, PO Box 110236, Beirut, Lebanon.
Marwan AtallahOphthalmology Department, American University of Beirut Medical Center, PO Box 110236, Beirut, Lebanon.
Larissa SmeetsOphthalmology Department, American University of Beirut Medical Center, PO Box 110236, Beirut, Lebanon.
Hasan ChahineOphthalmology Department, American University of Beirut Medical Center, PO Box 110236, Beirut, Lebanon.
American University of Beirut Medical Center · LB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo identify whether there are functional abnormalities in the retina of amblyopic eyes using multifocal electroretinography (mfERG).

methodsThis is a prospective study of patients ≥ 7 years of age identified with unilateral amblyopia (strabismic or anisometropic). Multifocal ERG and flash ERG were performed to compare parameters between the amblyopic and non-amblyopic fellow eyes. A complete analysis of the five ring averages was done including the central ring.

resultsThirty-eight patients were included: mean age was 14.3 ± 7.3 years; 18 patients were strabismic and 20 were anisometropic. Amblyopic eye responses across the rings in multifocal ERG were diminished compared with fellow non-amblyopic eyes with significant differences detected in the central rings (p = 0.001). On the other hand, flash ERG did not show any consistently significant differences. When divided by severity, amplitudes of central rings were significantly lower in severely amblyopic eyes compared with non-amblyopic eyes (p = 0.001), while in mild amblyopia, no significant differences were observed. No significant difference was observed between anisometropic and strabismic amblyopic eyes.

conclusionsUsing multifocal ERG, significantly decreased amplitudes were observed in amblyopic eyes compared with normal fellow eyes in the central ring. This correlated with the severity of amblyopia. No difference was observed when comparing the two groups of amblyopia (strabismic and anisometropic). Those findings may help clarify the pathophysiology of amblyopia better and open the door for new objective ways to monitor the response to amblyopia treatment but this needs to be further studied.

Indexed as

Visual AcuityAdolescentAmblyopiaChildElectroretinographyEvoked Potentials, VisualFemaleHumansMaleNerve FibersProspective StudiesRetinaTomography, Optical CoherenceVisual FieldsAmblyopiaElectroretinographyMultifocal electroretinographyVisual cortex

Identifiers

PMID31900648
OpenAlexW2997415527

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.