Evidence map›Paper›PMID 31900644›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2020

Multimodal imaging characterization of peripheral drusen.

Eleonora Corbelli, Enrico Borrelli, Mariacristina Parravano, Riccardo Sacconi, Marta Gilardi, Eliana Costanzo, Michele Cavalleri, Lea Querques, Francesco Bandello, Giuseppe Querques

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Age-Related Macular or Retinal Degeneration?Medicina (Kaunas, Lithuania) · 2023
    Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Eleonora CorbelliDepartment of Ophthalmology, University Vita-Salute Raffaele, Via Olgettina 60, Milan, Italy.
Enrico BorrelliDepartment of Ophthalmology, University Vita-Salute Raffaele, Via Olgettina 60, Milan, Italy.
Mariacristina ParravanoIRCCS- Fondazione Bietti, Rome, Italy.
Riccardo SacconiDepartment of Ophthalmology, University Vita-Salute Raffaele, Via Olgettina 60, Milan, Italy.
Marta GilardiIRCCS- Fondazione Bietti, Rome, Italy.
Eliana CostanzoIRCCS- Fondazione Bietti, Rome, Italy.
Michele CavalleriDepartment of Ophthalmology, University Vita-Salute Raffaele, Via Olgettina 60, Milan, Italy.
Lea QuerquesDepartment of Ophthalmology, University Vita-Salute Raffaele, Via Olgettina 60, Milan, Italy.
Francesco BandelloDepartment of Ophthalmology, University Vita-Salute Raffaele, Via Olgettina 60, Milan, Italy.
Giuseppe QuerquesDepartment of Ophthalmology, University Vita-Salute Raffaele, Via Olgettina 60, Milan, Italy. giuseppe.querques@hotmail.it.ORCID http://orcid.org/0000-0002-3292-9581
Vita-Salute San Raffaele University · ITFondazione G.B. Bietti · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo provide an integrate multimodal imaging characterization of peripheral drusen in the eyes with and without macular signs of age-related macular degeneration (AMD) and to analyze their association with macular findings.

methodsIn this retrospective, cross-sectional study, subjects with peripheral drusen were imaged with the Optos (Optos PLC, Dunfermline, Scotland, UK) and Spectralis devices to obtain referenced spectral domain optical coherence tomography (SD-OCT) images. Two experienced graders independently graded the ultra-widefield (UWF) pseudocolor and fundus autofluorescence (FAF) images for the presence of peripheral drusen and analyzed peripheral druse features using OCT. Main outcome measures included quantitative and qualitative assessment of peripheral drusen.

resultsFifty-seven eyes (30 subjects) were included in the analysis. Mean ± SD age was 77.6 ± 9.2 years (range 54-97 years). On pseudocolor images, graders identified the presence of drusen in all the enrolled eyes (Cohen's kappa was 1.0). On FAF images, Cohen's kappa was 0.71. In the topographical assessment, peripheral drusen were detected in 23 cases in the temporal region, in 40 cases in the nasal region, in 40 cases in the inferior region, and in 42 cases in the superior region. On SD-OCT images, peripheral drusen had a high reflective core in 97.1% of cases, while remaining drusen were characterized by a low reflective core. The macula was affected by early/intermediate AMD in 23 eyes (43.5%) and late AMD in 6 eyes (10.5%).

conclusionsWe provided an integrate multimodal imaging assessment of peripheral drusen in the eyes with and without AMD. Peripheral drusen were characterized by distinguished features that may suggest that these lesions constitute a distinct disease, rather than representing an expansion of AMD.

Indexed as

Multimodal ImagingAgedAged, 80 and overCross-Sectional StudiesFemaleFluorescein AngiographyFundus OculiHumansMaleMiddle AgedReproducibility of ResultsRetinaRetinal DrusenRetrospective StudiesTomography, Optical CoherenceAge-related macular degenerationDrusenMultimodal imagingPeripheral retinaUltra-widefield

Identifiers

PMID31900644
OpenAlexW2998531636

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.