Evidence map›Paper›PMID 31900618›Full record

Observational studySupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2020

A prospective study on oral adverse effects in head and neck cancer patients submitted to a preventive oral care protocol.

Marilia Oliveira Morais, Allisson Filipe Lopes Martins, Ana Paula Gonçalves de Jesus, Sebastião Silvério de Sousa Neto, Arthur Wilson Florêncio da Costa, Carlos Henrique Pereira, Angélica Ferreira Oton-Leite, Nilceana Maya Aires de Freitas, Cláudio Rodrigues Leles, Elismauro Francisco Mendonça

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 6 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 6 syntheses or guidelines pooled it, 53 citations in OpenAlex.

  1. Guideline
  2. The supportive use of photobiomodulation on salivary glands: a narrative review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
    Pooled it
  3. Impact of low-level laser therapy on the quality of life of patients with xerostomia undergoing head and neck radiotherapy: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Pooled it
  4. Pooled it
  5. Photobiomodulation therapy for the prevention of acute radiation dermatitis: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Pooled it
  6. Pooled it
  7. Effects of L-glutamine and hyaluronic acid associated with photobiomodulation on oral mucositis: a randomized clinical trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Trial
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  11. The use of photobiomodulation therapy for the prevention of chemotherapy-induced peripheral neuropathy: a randomized, placebo-controlled pilot trial (NEUROLASER trial).Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Trial
  12. Trial
  13. Review
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  17. Article
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  19. Interventions to improve quality of life in patients with head and neck cancers receiving radiation therapy: a scoping review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Marilia Oliveira MoraisSchool of Dentistry, Federal University of Goias, Goiania, Goias, Brazil.
Allisson Filipe Lopes MartinsSchool of Dentistry, Federal University of Goias, Goiania, Goias, Brazil.
Ana Paula Gonçalves de JesusSchool of Dentistry, Federal University of Goias, Goiania, Goias, Brazil.
Sebastião Silvério de Sousa NetoSchool of Dentistry, Federal University of Goias, Goiania, Goias, Brazil.
Arthur Wilson Florêncio da CostaSchool of Dentistry, Federal University of Goias, Goiania, Goias, Brazil.
Carlos Henrique PereiraSchool of Dentistry, Federal University of Goias, Goiania, Goias, Brazil.
Angélica Ferreira Oton-LeiteSchool of Dentistry, Federal University of Goias, Goiania, Goias, Brazil.
Nilceana Maya Aires de FreitasAraújo Jorge Hospital, Association of Cancer Combat of Goias, Goiania, Brazil.
Cláudio Rodrigues LelesSchool of Dentistry, Federal University of Goias, Goiania, Goias, Brazil.
Elismauro Francisco MendonçaSchool of Dentistry, Federal University of Goias, Goiania, Goias, Brazil. elismaur@ufg.br.ORCID http://orcid.org/0000-0002-6751-3279
Universidade Federal de Goiás · BRFundação Faculdade de Odontologia · BRHospital Araújo Jorge · BR

Funding

Fundação de Amparo à Pesquisa do Estado de Goiás (BR) 201410267000312
6 · The paper itself

Abstract

objectiveTo evaluate the occurrence and severity of oral complications, number of radiotherapy (RT) interruptions and quality of life (QoL) in a population of head and neck cancer patients receiving a preventive oral care program (POCP) and photobiomodulation therapy (PBMT).

methodsProspective cohort of 61 head and neck cancer patients undergoing radiochemotherapy were monitored and submitted to a POCP that included oral hygiene and plaque control, removal of infection foci, dental restorations, periodontal therapy, fluorotherapy, oral hydration, and denture removal at night, combined with daily PBMT. Outcomes included occurrence of adverse effects such as severity of oral mucositis (OM) and oral symptoms (pain, solid and fluid dysphagia, odynophagia, dysgeusia), quality of life impacts, and interruptions of radiotherapy (RT) due to symptoms. Disease-free and overall survival rates were evaluated.

resultsThere was a significant improvement in oral health conditions between initial assessment and the two longitudinal assessments (p < 0.05), which indicates that the POCP was effective for plaque control and reduction of gingival inflammation. All participants were free of OM at the beginning of the RT regimen and only 45.9% after the 7th session, and few patients ranked the highest score of OM. For all symptoms related to OM, there was a progressive increase of severity until the 14th RT session, which remained stable until the completion of the RT regimen. The same effect was observed for the quality of life measures. Discontinued RT due to OM occurred in only three patients (5%), and the maximum duration was 10 days. The overall survival rate was 77% and disease-free survival was 73.8%. Lower survival time was observed for patients with no response to RT (p < 0.01).

conclusionsThe findings of this study suggest a positive effect of an oral preventive care program for head and neck cancer patients submitted to RT. The PBMT associated with a rigorous POCP resulted in satisfactory control of oral adverse effects, reduction of quality of life impacts, and interruption of RT regimen due to severe OM.

Indexed as

AdultAgedChemoradiotherapyCohort StudiesFemaleHead and Neck NeoplasmsHumansLongitudinal StudiesLow-Level Light TherapyMaleMiddle AgedMouth DiseasesOral HealthOral HygieneProspective StudiesQuality of LifeHead and neck neoplasmsMucositisPreventive dentistryQuality of lifeRadiotherapy

Identifiers

PMID31900618
OpenAlexW2997872817

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.