Evidence map›Paper›PMID 31900579›Full record

ArticleEuropean journal of nutrition2020

Time course of tolerance to adverse effects associated with the ingestion of a moderate dose of caffeine.

Carlos Ruiz-Moreno, Beatriz Lara, Juan José Salinero, Diego Brito de Souza, José M Ordovás, Juan Del Coso

Abstract readControlled Clinical Trial
PubMed Publisher
In one paragraph

Article in European journal of nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 5 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 5 syntheses or guidelines pooled it, 55 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Carlos Ruiz-MorenoExercise Physiology Laboratory, Camilo José Cela University, Madrid, Spain.
Beatriz LaraExercise Physiology Laboratory, Camilo José Cela University, Madrid, Spain.
Juan José SalineroExercise Physiology Laboratory, Camilo José Cela University, Madrid, Spain.
Diego Brito de SouzaExercise Physiology Laboratory, Camilo José Cela University, Madrid, Spain.
José M OrdovásUSDA ARS, Human Nutrition Research Center On Aging At Tufts University, Boston, MA, 02111, USA.
Juan Del CosoCentre for Sport Studies, Rey Juan Carlos University, C/Camino del Molino, s/n, 28943, Fuenlabrada, Spain. juan.delcoso@urjc.es.ORCID http://orcid.org/0000-0002-5785-984X
Camilo José Cela University · ESMadrid Institute for Advanced Studies · ESUniversidad Rey Juan Carlos · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aimed to identify and describe the time course of tolerance to the most common caffeine-induced side effects.

methodsEleven participants took part in a crossover, double-blind placebo-controlled experimental design. In one phase, participants ingested 3 mg/kg/day of caffeine for 20 days, while in another phase, they ingested a placebo. Resting heart rate and blood pressure were measured three times per week during each 20-day phase and a quantitative survey was used to categorise the magnitude of side effects.

resultsIn the pairwise comparison with the placebo, the ingestion of caffeine increased systolic (+ 7.8 ± 10.1%, P < 0.05) and diastolic blood pressure (+ 6.4 ± 12.9% P < 0.05) for the first 8 days of ingestion, but then this effect became attenuated for both outcomes (on day 20, - 1.1 ± 4.3% and + 0.9 ± 9.6%, respectively). The ingestion of caffeine did not affect heart rate at any time point. Caffeine increased the feelings of nervousness and vigour and the rating of gastrointestinal complaints, insomnia and diuresis at several time points in the treatment (P < 0.05) and they did not disappear after 20 days of ingestion.

conclusionsThe daily intake of 3 mg/kg of caffeine induced a meaningful elevation in arterial blood pressure that disappeared after 8 days. However, other caffeine-induced effects such as increased nervousness and vigour, irritability, insomnia and diuresis remained after 20 days of consecutive caffeine ingestion. Although there was clear tolerance to the effect of caffeine on blood pressure, the persistence of other side effects suggests the inconvenience of maintaining a chronic caffeine intake, at least at the dose of 3 mg/kg/day.

Indexed as

AdultBlood PressureCaffeineCross-Over StudiesDouble-Blind MethodHeart RateHumansTime FactorsCaffeineBlood pressureHabituationHeart rateSide effectsStimulants

Identifiers

PMID31900579
OpenAlexW2997715951

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.