Evidence map›Paper›PMID 31900431›Full record

ArticleProstate cancer and prostatic diseases2020

Clinicopathologic features and outcomes of anterior-dominant prostate cancer: implications for diagnosis and treatment.

Sara M Falzarano, Yaw A Nyame, Jesse K McKenney, Christopher G Przybycin, Jianbo Li, Andrew Stephenson, Amr Fergany, Ming Zhou, Eric A Klein, Cristina Magi-Galluzzi

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Prostate cancer and prostatic diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
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  5. Prostate zones and cancer: lost in transition?Nature reviews. Urology · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Sara M Falzarano *Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, USA.
Yaw A Nyame *Department of Urology, Division of Public Health Sciences, Fred Hutchinson Cancer Research, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-8799-6749
Jesse K McKenneyRobert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.
Christopher G PrzybycinRobert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.
Jianbo LiQuantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA.
Andrew StephensonGlickman Urological Institute, Cleveland Clinic, Cleveland, OH, USA.
Amr FerganyGlickman Urological Institute, Cleveland Clinic, Cleveland, OH, USA.
Ming ZhouDepartment of Pathology, TUFTS Medical Center, Boston, MA, USA.
Eric A KleinGlickman Urological Institute, Cleveland Clinic, Cleveland, OH, USA.ORCID http://orcid.org/0000-0002-1783-0698
Cristina Magi-GalluzziDepartment of Pathology, Divison of Anatomic Pathology, University of Alabama at Birmingham, Birmingham, AL, USA. cmagigalluzzi@uabmc.edu.
Cleveland Clinic · USTufts Medical Center · USUniversity of Alabama at Birmingham · USUniversity of Florida · USUniversity of Washington · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aims to describe the pathological features and clinical outcomes in anterior-dominant prostate cancer (APCA) compared to posterior/posterolateral-dominant prostate cancer (PPCA) among men treated with radical prostatectomy for localized prostate cancer.

methodsThis is a single-institution, matched case-control analysis of short-term clinical outcomes stratified by pathologic tumor location at radical prostatectomy. Pathologic data extracted by expert genitourinary pathologists on tumor location was linked to clinical and oncologic outcomes data from a prospective institutional database for analysis.

resultsFrom 2005 to 2013, 1580 patients were identified for analysis with 150 (9.5%) having APCA. One-hundred and thirty two of these APCA men had complete clinical data and were matched to 353 men with PPCA (~1:3 ratio) by GrdGrp at surgery, margin status, and pathologic T stage. There were no racial/ethnic differences between APCA and PPCA (p = 0.13). Men with APCA demonstrated a higher median PSA at diagnosis (6.4 [4.6-9.1] ng/mL vs 5.6 [4.4-8.1] ng/mL; p = 0.04), a higher rate of GrdGrp 1 disease at diagnosis (57.7% vs. 40.0%, p = 0.003), and lower rates of abnormal digital rectal examination (DRE) (10.1% vs. 23.2%, p = 0.003) when compared to PPCA. The rate of surgical upgrading was higher among men with APCA vs. PPCA (55.3% vs 42.0%, p = 0.015). Freedom from biochemical failure (BF) at 5-years was 85.1% (95% CI 73.1-98.9) for APCA and 82.9% (95% CI 69.2-99.5) for men with PPCA (p = 0.70, log-rank test).

conclusionsThe majority of anterior tumors were undetectable by DRE and were associated with higher PSA at diagnosis. Despite presenting mostly as low/intermediate grade cancers, more than half of the men with APCA had upgrading at surgery and slightly more than 40% had positive margins and/or extraprostatic disease. When matched to a cohort of posterior predominant tumors, no differences were seen in the rate of biochemical-failure after prostatectomy.

Indexed as

AgedCase-Control StudiesDigital Rectal ExaminationFollow-Up StudiesHumansKallikreinsMaleMiddle AgedNeoplasm GradingNeoplasm Recurrence, LocalProspective StudiesProstateProstatectomyProstate-Specific AntigenProstatic NeoplasmsRetrospective StudiesKallikreinsKLK3 protein, humanProstate-Specific Antigen

Identifiers

PMID31900431
OpenAlexW2998043056

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.