Evidence map›Paper›PMID 31900360›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Global shape of Toll activation is determined by

Neta Rahimi, Shari Carmon, Inna Averbukh, Farzaneh Khajouei, Saurabh Sinha, Eyal D Schejter, Naama Barkai, Ben-Zion Shilo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Neta RahimiDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot 761001, Israel.
Shari CarmonDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot 761001, Israel.
Inna AverbukhDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot 761001, Israel.ORCID 0000-0003-1863-205X
Farzaneh KhajoueiDepartment of Computer Science, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
Saurabh SinhaDepartment of Computer Science, University of Illinois at Urbana-Champaign, Urbana, IL 61801.ORCID 0000-0001-6033-7746
Eyal D SchejterDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot 761001, Israel.
Naama BarkaiDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot 761001, Israel.
Ben-Zion ShiloDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot 761001, Israel; benny.shilo@weizmann.ac.il.ORCID 0000-0003-4903-8889

Funding

Quantitative Regulatory Genomics: Networks, CIS-Regulatorycodes, and Phenotypic VariationR35GM131819 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI SINHA, SAURABH · 2019 to 2023
$1.8M
Quantitative Modeling of Sequence-to-Expression RelationshipR01GM114341 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI SINHA, SAURABH · 2015 to 2018
$1.0M
NIGMS NIH HHS R01 GM114341NIGMS NIH HHS R35 GM131819
6 · The paper itself

Abstract

Buffering variability in morphogen distribution is essential for reproducible patterning. A theoretically proposed class of mechanisms, termed "distal pinning," achieves robustness by combining local sensing of morphogen levels with global modulation of gradient spread. Here, we demonstrate a critical role for morphogen sensing by a gene enhancer, which ultimately determines the final global distribution of the morphogen and enables reproducible patterning. Specifically, we show that, while the pattern of Toll activation in the early

Indexed as

AnimalsBinding SitesBody PatterningDrosophilaDrosophila ProteinsEmbryonic DevelopmentEnhancer Elements, GeneticGastrulaGene DosageGene Expression Regulation, DevelopmentalHMGB ProteinsIntracellular Signaling Peptides and ProteinsMorphogenesisRepressor ProteinsSequence AlignmentSignal Transductioncic protein, DrosophilaDrosophila ProteinsHMGB ProteinsIntracellular Signaling Peptides and ProteinsRepressor ProteinsTl protein, DrosophilaToll-Like ReceptorsWntD protein, DrosophilaDrosophilaembryogenesisintegral feedbackmorphogen gradientsToll signaling

Identifiers

PMID31900360
PMCPMC6983375

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.