Evidence map›Paper›PMID 31900356›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Cryo-EM analysis of a feline coronavirus spike protein reveals a unique structure and camouflaging glycans.

Tzu-Jing Yang, Yen-Chen Chang, Tzu-Ping Ko, Piotr Draczkowski, Yu-Chun Chien, Yuan-Chih Chang, Kuen-Phon Wu, Kay-Hooi Khoo, Hui-Wen Chang, Shang-Te Danny Hsu

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed
14.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 120 citations in OpenAlex.

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  11. Antiviral activity ofThe veterinary quarterly · 2024
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  19. Variations inBiomolecules · 2023
    Article
  20. Review

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Tzu-Jing YangInstitute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan.ORCID 0000-0003-1798-7764
Yen-Chen ChangInstitute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan.ORCID 0000-0002-4971-4237
Tzu-Ping KoInstitute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan.ORCID 0000-0003-1794-2638
Piotr DraczkowskiInstitute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan.ORCID 0000-0002-9408-2670
Yu-Chun ChienInstitute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan.
Yuan-Chih ChangInstitute of Cellular and Organismic Biology, Academia Sinica, Taipei 11529, Taiwan.ORCID 0000-0002-0289-3768
Kuen-Phon WuInstitute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan.ORCID 0000-0002-1525-6004
Kay-Hooi KhooInstitute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan.
Hui-Wen ChangGraduate Institute of Molecular and Comparative Pathobiology, School of Veterinary Medicine, National Taiwan University, Taipei 10617, Taiwan; huiwenchang@ntu.edu.tw sthsu@gate.sinica.edu.tw.ORCID 0000-0001-8877-1886
Shang-Te Danny HsuInstitute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan; huiwenchang@ntu.edu.tw sthsu@gate.sinica.edu.tw.ORCID 0000-0002-7231-0185
National Taiwan University · TWInstitute of Biological Chemistry, Academia Sinica · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Feline infectious peritonitis virus (FIPV) is an alphacoronavirus that causes a nearly 100% mortality rate without effective treatment. Here we report a 3.3-Å cryoelectron microscopy (cryo-EM) structure of the serotype I FIPV spike (S) protein, which is responsible for host recognition and viral entry. Mass spectrometry provided site-specific compositions of densely distributed high-mannose and complex-type N

Indexed as

Coronavirus, FelineCryoelectron MicroscopyGalectinsGlycosylationHEK293 CellsHumansMannoseProtein ConformationSpike Glycoprotein, CoronavirusGalectinsMannoseSpike Glycoprotein, Coronavirusalphacoronaviruscryoelectron microscopyfeline infectious peritonitis virusmass spectrometryprotein glycosylation

Identifiers

PMID31900356
PMCPMC6983407
OpenAlexW2996962756

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.