Evidence map›Paper›PMID 31900338›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2020

BHLHE40 Promotes T

Nicholas N Jarjour, Tara R Bradstreet, Elizabeth A Schwarzkopf, Melissa E Cook, Chin-Wen Lai, Stanley Ching-Cheng Huang, Reshma Taneja, Thaddeus S Stappenbeck, Steven J Van Dyken, Joseph F Urban and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 38 citations in OpenAlex.

  1. Review
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  9. Innateness transcriptome gradients characterize mouse T lymphocyte populations.Journal of immunology (Baltimore, Md. : 1950) · 2025
    Article
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  14. Steady-state memory-phenotype conventional CD4Experimental & molecular medicine · 2023
    Article
  15. Review
  16. Review
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Nicholas N JarjourDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0001-9400-4448
Tara R BradstreetDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110.
Elizabeth A SchwarzkopfDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110.
Melissa E CookDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110.
Chin-Wen LaiDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0002-7691-009X
Stanley Ching-Cheng HuangDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0002-6557-3737
Reshma TanejaDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore; and.ORCID 0000-0001-6214-6177
Thaddeus S StappenbeckDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0002-6023-3901
Steven J Van DykenDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0002-9787-0883
Joseph F UrbanDiet, Genomics and Immunology Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, United States Department of Agriculture, Beltsville, MD 20705.ORCID 0000-0002-1590-8869
Brian T EdelsonDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110; bedelson@path.wustl.edu.ORCID 0000-0003-2856-7650
Washington University in St. Louis · USAgricultural Research Service · USNational University of Singapore · SG

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
The Cleveland Digestive Diseases Research Core Center (DDRCC)P30DK097948 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI AMITABH CHAK · 2015 to 2026
$15.6M
TRAINING PROGRAM IN IMMUNOLOGY AND IMMUNOGENETICST32AI007163 · NIAID · WASHINGTON UNIVERSITY · PI Kenneth M Murphy, Kodi S Ravichandran · 1985 to 2026
$14.8M
Regulation of Immune Responses to Mycobacterium tuberculosis InfectionR01AI132653 · NIAID · WASHINGTON UNIVERSITY · PI EDELSON, BRIAN TODD, STALLINGS, CHRISTINA LEIGH · 2018 to 2022
$3.0M
UNDERSTANDING AUTOREACTIVE T CELL PATHOGENICITYR01AI113118 · NIAID · WASHINGTON UNIVERSITY · PI EDELSON, BRIAN TODD · 2015 to 2019
$1.9M
NCATS NIH HHS UL1 TR002345NIAID NIH HHS R01 AI113118NIAID NIH HHS R01 AI132653NIAID NIH HHS T32 AI007163NIDDK NIH HHS P30 DK097948
6 · The paper itself

Abstract

The transcription factor BHLHE40 is an emerging regulator of the immune system. Recent studies suggest that BHLHE40 regulates type 2 immunity, but this has not been demonstrated in vivo. We found that BHLHE40 is required in T cells for a protective T

Indexed as

AnimalsBasic Helix-Loop-Helix ProteinsCytokine Receptor Common beta SubunitDisease Models, AnimalFemaleGranulocyte-Macrophage Colony-Stimulating FactorHomeodomain ProteinsImmunity, CellularInterleukin-5MiceMice, KnockoutMucous MembraneNematospiroides dubiusStrongylida InfectionsTh2 CellsTranscription, GeneticBasic Helix-Loop-Helix ProteinsBhlhe40 protein, mouseCsf2rb protein, mouseCytokine Receptor Common beta SubunitGranulocyte-Macrophage Colony-Stimulating FactorHomeodomain ProteinsInterleukin-5

Identifiers

PMID31900338
PMCPMC7002269
OpenAlexW2997471285

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.