Evidence map›Paper›PMID 31900337›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2020

Vinpocetine Suppresses

Kensei Komatsu, Dae-Hwan Nam, Ji-Yun Lee, Go Yoneda, Chen Yan, Jian-Dong Li

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Dysregulation of immune response in otitis media.Expert reviews in molecular medicine · 2021
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Kensei KomatsuCenter for Inflammation, Immunity and Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303.
Dae-Hwan NamCenter for Inflammation, Immunity and Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303.
Ji-Yun LeeCenter for Inflammation, Immunity and Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303.ORCID 0000-0002-9370-3981
Go YonedaCenter for Inflammation, Immunity and Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303.ORCID 0000-0002-8427-1478
Chen YanAab Cardiovascular Research Institute and Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642.
Jian-Dong LiCenter for Inflammation, Immunity and Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303; jdli@gsu.edu.
Georgia State University · USUniversity of Rochester Medical Center · US

Funding

Regulation and Function of Phosphodiesterase in the HeartR01HL088400 · NHLBI · UNIVERSITY OF ROCHESTER · PI YAN, CHEN · 2008 to 2018
$3.1M
Development of innovative therapeutics for otitis mediaR01DC015557 · NIDCD · GEORGIA STATE UNIVERSITY · PI KOHANE, DANIEL S, LI, JIAN-DONG · 2018 to 2022
$2.9M
PDE10A Regulation and Function in Cardiovascular DiseaseR01HL134910 · NHLBI · UNIVERSITY OF ROCHESTER · PI BERK, BRADFORD C, YAN, CHEN · 2017 to 2020
$2.1M
Pathogenesis of pneumococcal otitis mediaR01DC013833 · NIDCD · GEORGIA STATE UNIVERSITY · PI LI, JIAN-DONG · 2015 to 2019
$1.6M
NHLBI NIH HHS R01 HL088400NHLBI NIH HHS R01 HL134910NIDCD NIH HHS R01 DC013833NIDCD NIH HHS R01 DC015557
6 · The paper itself

Abstract

Otitis media (OM) is the most common bacterial infection in children. It remains a major health problem and a substantial socioeconomic burden.

Indexed as

AnimalsCell LineDeubiquitinating Enzyme CYLDDisease Models, AnimalEar, MiddleEpithelial CellsGene Knockdown TechniquesHumansMAP Kinase Signaling SystemMiceMice, KnockoutMitogen-Activated Protein Kinase 3Otitis MediaPneumococcal InfectionsRNA, Small InterferingStreptococcus pneumoniaeCYLD protein, humanCYLD protein, mouseDeubiquitinating Enzyme CYLDMAPK3 protein, humanMapk3 protein, mouseMitogen-Activated Protein Kinase 3RNA, Small InterferingVinca Alkaloidsvinpocetine

Identifiers

PMID31900337
PMCPMC8406682
OpenAlexW2998286622

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.